Flt-3
Flt-3 (FMS-like tyrosine kinase 3, CD135) is a class III receptor tyrosine kinase bearing five extracellular immunoglobulin-like domains. Binding of its ligand, Flt3 ligand, induces dimerization and activation that is essential for the proliferation and survival of hematopoietic stem and progenitor cells as well as dendritic cell development. In acute myeloid leukemia, FLT3 is among the most frequently mutated genes, with internal tandem duplications in the juxtamembrane domain or activating point mutations in the activation loop driving constitutive signaling and poor prognosis. These features established FLT3 as a validated target, and inhibitors such as midostaurin, gilteritinib, and quizartinib are used in AML therapy.
-
Flt-3 Recombinant Proteins (9)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
