IKK
The IKK family is the convergence point for NF-kappaB signaling and contains two canonical catalytic subunits, IKK alpha (CHUK) and IKK beta (IKBKB), together with the related IKK epsilon (IKBKE) and TBK1. In the canonical pathway IKK beta, within the IKK alpha/beta/gamma (NEMO) complex, phosphorylates I kappa B alpha, triggering ubiquitination and degradation and thereby releasing NF-kappaB; IKK alpha mediates the non-canonical p100-to-p52 route. IKK epsilon and TBK1 act in innate immunity, phosphorylating IRF3 and STING to induce type I interferon, and also support selective autophagy and tumor cell survival. NEMO loss-of-function mutations cause incontinentia pigmenti, and TBK1 inhibitors are in oncology trials.
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IKK Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
