IRE
Inositol-requiring enzyme 1 comprises IRE1 alpha (ERN1) and the more restricted IRE1 beta (ERN2). Each is an endoplasmic reticulum transmembrane protein with a luminal stress-sensing domain, a cytosolic kinase domain and an endoribonuclease domain; accumulation of misfolded protein drives oligomerization and trans-autophosphorylation, which licenses the RNase. IRE1 alpha then splices XBP1 mRNA to generate the transcription factor XBP1s that expands ER folding capacity, and also degrades selected mRNAs through regulated IRE1-dependent decay (RIDD). IRE1 beta is expressed in intestinal and airway epithelium, where it dampens XBP1 splicing. Persistent activation contributes to inflammatory, metabolic and neoplastic adaptation, and inhibitors such as 4μ8C, KIRA6 and STF-083010 are widely used tools.
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IRE Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
