RB-07-16
RB-07-16 is a C6-PyraP-BP inhibitor of human geranylammate pyrophosphate synthase (hGGPPS). RB-07-16 has antitumor activity.
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- CAS. Nr.: 3035023-20-9
- Formel: C21H19F3N6O7P2
- Molecular Weight:586.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | EC50 |
580 nM
Compound: 13e; RB-07-16
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
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[PMID: 37982711] |
| MIA PaCa-2 | EC50 |
790 nM
Compound: 13e; RB-07-16
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Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
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[PMID: 37982711] |
| RPMI-8226 | EC50 |
70 nM
Compound: 13e; RB-07-16
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Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
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[PMID: 37982711] |
Chemical Information
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CAS. Nr. 3035023-20-9
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Molecular Weight 586.35
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Formel C21H19F3N6O7P2
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SMILES
CN1N=CC2=C1N=C(C3=CC=CC(C(NC4=CC=C(C(F)(F)F)C=C4)=O)=C3)N=C2NC(P(O)(O)=O)P(O)(O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Rebecca Boutin, et al. Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer. J Med Chem. 2023, 66, 23. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RB-07-16 Related Classifications
HY-161012 Related Classifications
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