Resolvin D4
Based on 1 Customer Validation
Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection.
The product specifications provided below refer solely to the active content of Resolvin D4.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 96.8%
- CAS. Nr.: 1025684-60-9
- Formel: C22H32O5
- Molecular Weight:376.49
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Speicherung:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Resolvin D2 methyl ester -
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PCTR2Pro-resolving Mediator -
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Biologische Aktivität
Beschreibung
In Vitro
Resolvin D4 (RvD4) stops neutrophil infiltration in sterile peritonitis and S. aureus skin infection[1].
Resolvin D4 (RvD4, 0-10 nM) enhances human macrophage and dermal fibroblast phagocytosis and efferocytosis[1].
Resolvin D4 (RvD4, 0-10 nM) statistically significantly increases macrophage efferocytosis of apoptotic neutrophils by 40-50%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Resolvin D4 (RvD4, 10 ng/mouse) modulates the severity of thrombo-inflammatory disease in vivo and improves thrombus resolution[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8-week-old male FVB mice (a self-limited bacterial inoculation (105 c.f.u) into the dorsal pouch)[1].
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Dosage:200 ng/mouse (saline containing 0.01% EtOH).
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Administration:I.P..
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Result:Gave lower PMN levels in the cavity in mice treated with RvD4.
Significantly lowered bacterial counts when compared to vehicle control.
Stopped leukocyte influx to the site of infection in the dorsal pouch cavity as well as the inflammation-initiating eicosanoids by reducing levels of PGD2 and LTB4.
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Animal Model:Thrombus-bearing mice[2].
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Dosage:3 µg.
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Administration:IV via tail vein injection on day 1 and day 4 after IVC stenosis.
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Result:Accelerated venous thrombus resolution in mice.
Chemical Information
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CAS. Nr. 1025684-60-9
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Appearance Liquid
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Molecular Weight 376.49
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Formel C22H32O5
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Color Colorless to light yellow
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SMILES
CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCC(O)=O
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Synonyms
RvD4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Jeremy W Winkler, et al. Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance. Sci Rep. 2016 Jan 8:6:18972. [Content Brief]
[2]. Deya Cherpokova, et al. Resolvin D4 attenuates the severity of pathological thrombosis in mice. Blood. 2019 Oct 24;134(17):1458-1468. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Resolvin D4 Related Classifications
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