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Rovalpituzumab

(Synonyms: SC-0001)
1 Cited Publications
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Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC).

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  • Reinheit: 99.84%
  • CAS. Nr.: 1613313-01-1
  • Molecular Weight:145.02 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Rovalpituzumab
  • Experimental Validation Results for Rovalpituzumab
  • Experimental Validation Results for Rovalpituzumab
  • Rovalpituzumab Chemical Structure
    Rovalpituzumab Chemical Structure
CAS. Nr.: 1613313-01-1
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His, HY-P78115) can bind Rovalpituzumab. The EC50 for this effect is 3.245 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 U118MG cells with Rovalpituzumab (HY-P99043, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Rovalpituzumab Chemical Structure
    1/16
  • Rovalpituzumab
  • Immobilized Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His, HY-P78115) can bind Rovalpituzumab. The EC50 for this effect is 3.245 ng/mL.
  • Flow cytometric analysis of 1X106 U118MG cells with Rovalpituzumab (HY-P99043, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).