S21-1011
S21-1011 is a selective inhibitor for butyrylcholinesterase (BChE), with IC50 of 0.059 and 0.162 μM, for eqBChE and hBChE, respectively. S21-1011 exhibits good blood-brain barrier (BBB) permeability and good pharmacokinetic characters. S21-1011 exhibits anti-inflammatory activity through activation of keap1-Nrf2-ARE pathway (EC50 is 23.48 μM for antioxidant element ARE activation), ameliorates cognitive impairment in murine Alzheimer’s disease model.
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- CAS. Nr.: 2671859-87-1
- Formel: C30H32N4O
- Molecular Weight:464.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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eqBCHE 0.059 μM (IC50) |
hBCHE 0.162 μM (IC50) |
Chemical Information
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CAS. Nr. 2671859-87-1
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Molecular Weight 464.60
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Formel C30H32N4O
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SMILES
CCCC1=CC=C(C(NC2=CN=C(C=CC=C3)C3=C2N4CCN(CC5=CC=CC=C5)CC4)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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