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Sabatolimab

(Synonyms: MBG453)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells.

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  • Reinheit: 99.00%
  • CAS. Nr.: 2252262-24-9
  • Molecular Weight:144.675 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sabatolimab
  • Experimental Validation Results for Sabatolimab
  • Experimental Validation Results for Sabatolimab
  • Sabatolimab Chemical Structure
    Sabatolimab Chemical Structure
CAS. Nr.: 2252262-24-9
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[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Flow cytometric analysis of 1.5X106 MCF-7 cells with Sabatolimab (HY-P99044, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.

  • 1/16

    Loaded Sabatolimab on AHC2 biosensor, can bind TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi,HY-P78217) with an affinity constant of 8.541E-11 M as determined in BLI assay.

  • Sabatolimab Chemical Structure
    1/16
  • Sabatolimab
  • Flow cytometric analysis of 1.5X106 MCF-7 cells with Sabatolimab (HY-P99044, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.
  • Loaded Sabatolimab on AHC2 biosensor, can bind TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi,HY-P78217) with an affinity constant of 8.541E-11 M as determined in BLI assay.