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Art. -Nr.: HY-178137

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SCR007

SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics.

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CAS. Nr.: 2409183-72-6
Formel: C₃₆H₃₀N₄S₄
Molecular Weight:646.91

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

SCR007 Chemical Structure

CAS. Nr.: 2409183-72-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Filovirus Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	>100 μM Compound: SCR-9	Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs	[PMID: 30925051]

In Vitro

SCR007 (10-40 μM) ) inhibits infection of SARS-CoV-2 (WA.1 strain), MERS-CoV, EBOV, MARV, NiV, and HeV in PRNT and IFA assays, with potent inhibitory efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SCR007 (3 mg/kg, i.n., single dose) improves survival rate in hACE2 mice infected SARS-CoV-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 10³ PFU of SARS-CoV-1/2^[1]
Dosage:

3 mg/kg
Administration:

i.n., single dose
Result:

Achieved 90% survival rate.
Reduced lung viral RNA copies by multiple orders of magnitude and brain viral RNA copies significantly.
Decreased perivascular infiltrates and necrotic neurons in lung and brain tissues.
Reduced lung live virus titer.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with TNFα, IL-18 and IFN-γ reduced.

Chemical Information

CAS. Nr. 2409183-72-6
Molecular Weight 646.91
Formel C₃₆H₃₀N₄S₄
SMILES

C1(C/N=C/C2=CC=CS2)=CC(C3=CC(C/N=C/C4=CC=CS4)=CC(C/N=C/C5=CC=CS5)=C3)=CC(C/N=C/C6=CC=CS6)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ezzatpour S, et al. Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families. Sci Adv. 2025 Aug 29;11(35):eady3554. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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SCR007

Alle Filovirus Isoform-spezifische Produkte anzeigen