Sideroxylin
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species (ROS).
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- CAS. Nr.: 3122-87-0
- Formel: C18H16O5
- Molecular Weight:312.32
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
>10 μM
Compound: S4
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Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
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[PMID: 30057155] |
| HT-29 | IC50 |
>10 μM
Compound: S4
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Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
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[PMID: 30057155] |
| MCF7 | IC50 |
14.7 μM
Compound: 2
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
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[PMID: 26086179] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: S4
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
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[PMID: 30057155] |
| MDA-MB-231 | IC50 |
36.9 μM
Compound: 2
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
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[PMID: 26086179] |
| MDA-MB-435 | IC50 |
>10 μM
Compound: S4
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Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
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[PMID: 30057155] |
| NIH3T3 | IC50 |
>40 μM
Compound: 2
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Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
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[PMID: 26086179] |
| OVCAR-3 | IC50 |
>10 μM
Compound: S4
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Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
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[PMID: 30057155] |
Chemical Information
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CAS. Nr. 3122-87-0
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Appearance Solid
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Molecular Weight 312.32
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Formel C18H16O5
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Color Light brown to brown
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SMILES
O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C)C(OC)=C(C)C(O)=C13
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 15.5 mg/mL (49.63 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2018 mL | 16.0092 mL | 32.0184 mL | 80.0461 mL |
| 5 mM | 0.6404 mL | 3.2018 mL | 6.4037 mL | 16.0092 mL | |
| 10 mM | 0.3202 mL | 1.6009 mL | 3.2018 mL | 8.0046 mL | |
| 15 mM | 0.2135 mL | 1.0673 mL | 2.1346 mL | 5.3364 mL | |
| 20 mM | 0.1601 mL | 0.8005 mL | 1.6009 mL | 4.0023 mL | |
| 25 mM | 0.1281 mL | 0.6404 mL | 1.2807 mL | 3.2018 mL | |
| 30 mM | 0.1067 mL | 0.5336 mL | 1.0673 mL | 2.6682 mL | |
| 40 mM | 0.0800 mL | 0.4002 mL | 0.8005 mL | 2.0012 mL |
Sideroxylin Related Classifications
HY-N1306 Related Classifications
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