SLU-12091
SLU-12091 is a phosphodiesterase (PDE) inhibitor and the more potent enantiomer of rac-11. SLU-12091 inhibits the activities of hPDE5, hPDE11, hPDE2A1, hPDE3A, hPDE3B, hPDE4A1A and hPDE4D2. SLU-12091 inhibits the growth of Cryptosporidium parvum without inhibiting the growth of host cells at the highest concentration tested. SLU-12091 can be used for the research of cryptosporidiosis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3065124-09-3
- Formel: C23H23BFN5O2
- Molecular Weight:431.27
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PDE5 |
PDE11 |
PDE2A |
PDE3A |
PDE3B |
PDE4A1 |
PDE4D2 |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | EC50 |
0.011 μM
|
Inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.
Inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.
|
42593902 |
| HCT-8 | EC90 |
0.020 μM
|
90% inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.
90% inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.
|
42593902 |
In Vitro
SLU-12091 (ent2-11) (0.011 μM; 48 h) potently inhibits Cryptosporidium parvum replication in HCT-8 cells with an EC50 of 11 nM and shows no cytotoxicity against HCT-8 cells up to 50 μM[1].
SLU-12091 (0.1-10 μM) inhibits multiple human PDE enzymes, with the strongest activity against hPDE5, hPDE4D2, hPDE3A, hPDE3B, and hPDE2A1 at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 3065124-09-3
-
Molecular Weight 431.27
-
Formel C23H23BFN5O2
-
SMILES
FC1=CC=C(C=C1)CNC2=NC(C3=CC=C4B(O[C@H](C4=C3)C)O)=NC5=C2C(CC)=NN5C
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SLU-12091 Related Classifications
HY-189060 Related Classifications
Powered by Bioz