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Art. -Nr.: HY-144645

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SP-471P

Name: SP-471P
Brand: MedChemExpress
SKU: HY-144645
Price: 425.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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SP-471P is a potent dengue virus (DENV) protease inhibitor with EC₅₀s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC₅₀ value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.

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Reinheit: 99.46%
CAS. Nr.: 2768011-36-3
Formel: C₃₃H₂₆BrN₅O₂
Molecular Weight:604.50

Speicherung:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

SP-471P Chemical Structure

CAS. Nr.: 2768011-36-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

EC₅₀: 5.9 μM (DENV1), 1.4 μM (DENV2), 5.1 μM (DENV3), 1.7 μM (DENV4)^[1]

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>100 μM Compound: 32a; SP-471P	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability	[PMID: 34298282]
PBMC	CC₅₀	>100 μM Compound: 32a; SP-471P	Cytotoxicity against human PBMC assessed as reduction in cell viability Cytotoxicity against human PBMC assessed as reduction in cell viability	[PMID: 34298282]

In Vitro

SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC₅₀s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively^[1].
SP-471P (10 μM; 48 hours) exhibits an EC₅₀ value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells^[1].
SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2^[1].
SP-471P (10 μM; 30 hours) targets the NS3_int cleavage site of DENV in DENV2-infected Huh7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:

Human peripheral blood mononuclear cells (infected with ADE)^[1]
Concentration:

10 μM
Incubation Time:

48 hours
Result:

Resulted in an EC₅₀ value of 1.5 μM for ADE infection in human PBMCs.

RT-PCR

Cell Line:

Huh7 (infected with DENV2 at MOI 1 for 6 hours)^[1]
Concentration:

10 μM
Incubation Time:

6-54 hours
Result:

Reduced viral RNA synthesis.

Western Blot Analysis

Cell Line:

Huh7 (infected with DENV2 at MOI 1 for 6 hours)^[1]
Concentration:

10 μM
Incubation Time:

30 hours
Result:

Targeted the NS3_int cleavage site of DENV.

Chemical Information

CAS. Nr. 2768011-36-3
Appearance Solid
Molecular Weight 604.50
Formel C₃₃H₂₆BrN₅O₂
Color White to off-white
SMILES

N/C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(/C(N)=N/O)=C6)=C4)=C2)=C1)=N\O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Swarbrick C, Zogali V, Chan KWK, et al. Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease. Eur J Med Chem. 2021;224:113695. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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SP-471P

NS2B/NS3-IN-2

SP-471

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen