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Art. -Nr.: HY-156088

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SSE1806

Name: SSE1806
Brand: MedChemExpress
SKU: HY-156088
Price: 94.00 USD
Availability: InStock
Rating: 5 (1 reviews)

SSE1806 is a derivative of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor with significant anticancer and antiproliferative activities. The GI50 of SSE1806 on cancer cell growth ranges from 1.29-21.15 μM. SSE1806 causes mitotic abnormalities and G2/M phase arrest, increases p53 expression, and inhibits colon cancer organoid growth. SSE1806 is able to overcome multidrug resistance in cell lines overexpressing MDR-1.

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CAS. Nr.: 3053861-26-7
Formel: C₂₁H₁₈N₂O₅
Molecular Weight:378.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

SSE1806 Chemical Structure

CAS. Nr.: 3053861-26-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	GI₅₀	7.05 μM Compound: SSE1806	Antitumor activity against human BT-549 cells by MTS assay Antitumor activity against human BT-549 cells by MTS assay	[PMID: 37849542]
CAL-51	GI₅₀	3.3 μM Compound: SSE1806	Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay	[PMID: 37849542]
HCC1954	GI₅₀	21.15 μM Compound: SSE1806	Antitumor activity against human HCC1954 cells by MTS assay Antitumor activity against human HCC1954 cells by MTS assay	[PMID: 37849542]
HCT-116	GI₅₀	2.01 μM Compound: SSE1806	Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay	[PMID: 37849542]
K562	GI₅₀	17.74 μM Compound: SSE1806	Antitumor activity against human K562 cells by MTS assay Antitumor activity against human K562 cells by MTS assay	[PMID: 37849542]
KB 3-1	GI₅₀	1.29 μM Compound: SSE1806	Antitumor activity against human KB-3-1 cells by MTS assay Antitumor activity against human KB-3-1 cells by MTS assay	[PMID: 37849542]
KB 3-1	GI₅₀	1.29 μM Compound: SSE1806	Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell proliferation Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell proliferation	[PMID: 37849542]
KB-V1	GI₅₀	1.74 μM Compound: SSE1806	Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell proliferation Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell proliferation	[PMID: 37849542]
MCF7	GI₅₀	5.02 μM Compound: SSE1806	Antitumor activity against human MCF7 cells by MTS assay Antitumor activity against human MCF7 cells by MTS assay	[PMID: 37849542]
MOLM-13	GI₅₀	4.23 μM Compound: SSE1806	Antitumor activity against human MOLM-13 cells by MTS assay Antitumor activity against human MOLM-13 cells by MTS assay	[PMID: 37849542]
MV4-11	GI₅₀	9.45 μM Compound: SSE1806	Antitumor activity against human MV4-11 cells by MTS assay Antitumor activity against human MV4-11 cells by MTS assay	[PMID: 37849542]

Chemical Information

CAS. Nr. 3053861-26-7
Molecular Weight 378.38
Formel C₂₁H₁₈N₂O₅
SMILES

O=C1CCCC2=C1C(C3=CC=CC([N+]([O-])=O)=C3)C4=CC(OCCO5)=C5C=C4N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Firdous F, et al. Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance[J]. ACS Medicinal Chemistry Letters, 2023...

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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