Sulfiram
Based on 1 Customer Validation
Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease.
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- Reinheit: 96.35%
- CAS. Nr.: 95-05-6
- Formel: C10H20N2S3
- Molecular Weight:264.47
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Biologische Aktivität
Sulfiram is a very weak inhibitor of mitochondrial ALDH in Saccharomyces cerevisiae, but undergoes phototransformation to form the potent ALDH inhibitor Disulfiram under indoor light or 350 nm irradiation, resulting in a time-dependent increase in ALDH inhibitory activity[1].
Sulfiram (1 μM; 24 h) enhances α-cleavage of APP and reduces its β-cleavage, increasing the α/β cleavage ratio in 7W-CHO cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 95-05-6
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Appearance Viscous Liquid
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Molecular Weight 264.47
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Formel C10H20N2S3
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Color Light yellow to yellow
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SMILES
S=C(N(CC)CC)SC(N(CC)CC)=S
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (378.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Mays DC, et al. Photolysis of sulfiram: a mechanism for its disulfiram-like reaction. Biochem Pharmacol. 1994;48(10):1917-1925. [Content Brief]
[2]. Libeu CA, et al. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012;7(6):e40027. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7811 mL | 18.9057 mL | 37.8115 mL | 94.5287 mL |
| 5 mM | 0.7562 mL | 3.7811 mL | 7.5623 mL | 18.9057 mL | |
| 10 mM | 0.3781 mL | 1.8906 mL | 3.7811 mL | 9.4529 mL | |
| 15 mM | 0.2521 mL | 1.2604 mL | 2.5208 mL | 6.3019 mL | |
| 20 mM | 0.1891 mL | 0.9453 mL | 1.8906 mL | 4.7264 mL | |
| 25 mM | 0.1512 mL | 0.7562 mL | 1.5125 mL | 3.7811 mL | |
| 30 mM | 0.1260 mL | 0.6302 mL | 1.2604 mL | 3.1510 mL | |
| 40 mM | 0.0945 mL | 0.4726 mL | 0.9453 mL | 2.3632 mL | |
| 50 mM | 0.0756 mL | 0.3781 mL | 0.7562 mL | 1.8906 mL | |
| 60 mM | 0.0630 mL | 0.3151 mL | 0.6302 mL | 1.5755 mL | |
| 80 mM | 0.0473 mL | 0.2363 mL | 0.4726 mL | 1.1816 mL | |
| 100 mM | 0.0378 mL | 0.1891 mL | 0.3781 mL | 0.9453 mL |
Sulfiram Related Classifications
HY-121817 Related Classifications
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