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Art. -Nr.: HY-125480

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T5996207

T5996207 is a MyD88 inhibitor. T5996207 inhibits LPS-induced MyD88-mediated NF-κB-driven SEAP expression. T5996207 protects mice from lethal staphylococcal enterotoxin B-induced shock. T5996207 can be used for research on acute lung injury and toxic shock.

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CAS. Nr.: 950003-29-9
Formel: C₂₀H₂₈N₄O₃S₂
Molecular Weight:436.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

T5996207 Chemical Structure

CAS. Nr.: 950003-29-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NF-κB Isoform-spezifische Produkte anzeigen :

In Vitro

Innate ImmunityCytokines & Chemokines

Innate Immunity

T5996207 (IC₅₀ = 40-50 μM) specifically inhibits MyD88-mediated NF-κB driven SEAP activity in HEK 293T cells by directly binding to the TIR domain^[2].

Innate Immunity

Cytokines & Chemokines

T5996207 (5 million compounds) was identified as a MyD88 TIR inhibitor through in silico high-throughput screening of 5 million compounds followed by chemical similarity searching^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bacterial InfectionCytokines & Chemokines

Bacterial Infection

Cytokines & Chemokines

T5996207 protects mice from lethal Staphylococcus enterotoxin B-induced shock by disrupting MyD88 TIR-TIR interactions^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 950003-29-9
Molecular Weight 436.59
Formel C₂₀H₂₈N₄O₃S₂
SMILES

O=C(NCC=1SC(=CC1)S(=O)(=O)N(CC)CC)N2CCN(C=3C=CC=CC3)CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhu L, et al. Design, Synthesis, and Biological Evaluation of a MyD88-Targeted Molecular Glue d21 for the Treatment of Acute Lung Injury. Journal of medicinal chemistry. 2026 Jun 25;69(12):14722-14740. [Content Brief]

[2]. Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Scientific reports. 2015 Sep 18;5:14246. [Content Brief]

[3]. Chen P. Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury. Journal of Medicinal Chemistry. 2025 Sep 12;68(18):19626-44. [Content Brief]

[4]. Chen L. Myeloid differentiation primary response protein 88 (MyD88): the central hub of TLR/IL-1R signaling. Journal of medicinal chemistry. 2020 Sep 15;63(22):13316-29. [Content Brief]

[5]. Olson M A, et al. Author Correction: Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen[J]. Scientific Reports, 2018, 8(1): 17074.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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