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Art. -Nr.: HY-139102

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Thailanstatin B

Thailanstatin B is a potent pre-mRNA splicing inhibitor (IC₅₀=6.18 μM). Thailanstatin B shows antiproliferative activity.

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CAS. Nr.: 1426953-23-2
Formel: C₂₈H₄₂ClNO₉
Molecular Weight:572.09

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Thailanstatin B Chemical Structure

CAS. Nr.: 1426953-23-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Thailanstatin B is a potent pre-mRNA splicing inhibitor (IC₅₀=6.18 μM). Thailanstatin B shows antiproliferative activity^[1].

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	>100 nM Compound: 10	Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
DU-145	GI₅₀	3 nM Compound: 2	Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]
HEK293	IC₅₀	6.18 μM Compound: 2	Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay	[PMID: 23517093]
HEK-293T	IC₅₀	193.7 nM Compound: 6	Cytotoxicity against HEK293T cells assessed as inhibition in cell growth Cytotoxicity against HEK293T cells assessed as inhibition in cell growth	[PMID: 33974423]
MDA-MB-231	GI₅₀	6.22 nM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]
MDA-MB-468	IC₅₀	>100 nM Compound: 10	Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
MES-SA	IC₅₀	856.3 nM Compound: 6	Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth	[PMID: 33974423]
MES-SA/Dx5	IC₅₀	>1000 nM Compound: 6	Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth	[PMID: 33974423]
NCI-N87	IC₅₀	>100 nM Compound: 10	Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
SK-OV-3	GI₅₀	4.94 nM Compound: 2	Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]

In Vitro

Thailanstatin B exhibits potent antiproliferative activities with GI₅₀s 2.5-4.94 nM for DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1426953-23-2
Molecular Weight 572.09
Formel C₂₈H₄₂ClNO₉
SMILES

C[C@@H](C[C@H]([C@H](O1)C)NC(/C=C\[C@H](C)OC(C)=O)=O)[C@@H]1C/C=C(C)/C=C/[C@@H]2[C@H]([C@@](O)(C[C@H](O2)CC(O)=O)CCl)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu X, et al. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod. 2013;76(4):685-693. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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Chemical Information
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Thailanstatin B

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

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Calculators

Help & FAQs

Thailanstatin B Related Classifications

HY-139102 Related Classifications