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Art. -Nr.: HY-189716

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TOFyl-CoA

TOFyl-CoA is an intracellular metabolite of TOFA (HY-101068) and a more potent ACC inhibitor. TOFyl-CoA exerts allosteric inhibition on ACC1 and ACC2 by competing with acetyl-CoA in the carboxyltransferase reaction.

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CAS. Nr.: 71865-60-6
Formel: C₄₀H₆₆N₇O₁₉P₃S
Molecular Weight:1073.97

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TOFyl-CoA Chemical Structure

CAS. Nr.: 71865-60-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

ACC1

ACC2

In Vitro

Lipid Metabolism

TOFyl-CoA (500 μM top dose; 10-fold serial dilution to 8 concentrations) inhibits both ACC1 and ACC2 enzymes with greater potency than TOFA in cell-free ACC1 and ACC2 activity assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 71865-60-6
Molecular Weight 1073.97
Formel C₄₀H₆₆N₇O₁₉P₃S
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(C4=CC=C(OCCCCCCCCCCCCCC)O4)=O)=O)=O)O)C)=O)=O)O3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Pizzorno J, et al. Health Medicine. Integrative medicine (Encinitas, Calif.). 2022 Dec;21(6):8-14. [Content Brief]

[2]. Huang H, et al. Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acid β-Oxidative Genes: Synergistic Roles of L-FABP and Glucose. PPAR Res. 2013;2013:865604. https://doi.org/10.1155/2013/865604

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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