TREX1-IN-1
Based on 1 publication(s) in Google Scholar
TREX1-IN-1 is a TREX1 inhibitor with an IC50 value for hTREX1 less than 0.1 μM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.32%
- CAS. Nr.: 2756594-27-9
- Formel: C19H18FN3O5
- Molecular Weight:387.36
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) TREX1-IN-1
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Biologische Aktivität
three prime repair exonuclease 1 (TREX1)[1]
TREX1-IN-1 (Compound 180) (1.5 nM-300 μM，30 min) inhibits TREX1 enzyme with an IC50 value less than 0.1 μM in enzyme activity assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57BL/6J inoculated with MC38 cells and BALB/c mice inoculated with 4T1-Mlh1⁻/⁻ cells.
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Dosage:120 μg
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Administration:intratumoral, i.t; once daily for 4 days
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Result:Significantly inhibited the growth of dMMR tumors.
Prevented the degradation of cytoplasmic dsDNA by TREX1, activated the endogenous cGAS-STING-IFN-I-MHC I upregulation within the tumor, and triggered CD8⁺ T cell-dependent anti-tumor immunity.
Chemical Information
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CAS. Nr. 2756594-27-9
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Appearance Solid
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Molecular Weight 387.36
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Formel C19H18FN3O5
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Color White to off-white
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SMILES
O=C(C1=CC=C2N=C(N(C3(COC3)C)C2=C1)C4=C(F)C(O)=C(O)C(OC)=C4)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Exp Med
2025 Dec 1;222(12):e20250265. PMID: 41055714
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (258.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5816 mL | 12.9079 mL | 25.8158 mL | 64.5394 mL |
| 5 mM | 0.5163 mL | 2.5816 mL | 5.1632 mL | 12.9079 mL | |
| 10 mM | 0.2582 mL | 1.2908 mL | 2.5816 mL | 6.4539 mL | |
| 15 mM | 0.1721 mL | 0.8605 mL | 1.7211 mL | 4.3026 mL | |
| 20 mM | 0.1291 mL | 0.6454 mL | 1.2908 mL | 3.2270 mL | |
| 25 mM | 0.1033 mL | 0.5163 mL | 1.0326 mL | 2.5816 mL | |
| 30 mM | 0.0861 mL | 0.4303 mL | 0.8605 mL | 2.1513 mL | |
| 40 mM | 0.0645 mL | 0.3227 mL | 0.6454 mL | 1.6135 mL | |
| 50 mM | 0.0516 mL | 0.2582 mL | 0.5163 mL | 1.2908 mL | |
| 60 mM | 0.0430 mL | 0.2151 mL | 0.4303 mL | 1.0757 mL | |
| 80 mM | 0.0323 mL | 0.1613 mL | 0.3227 mL | 0.8067 mL | |
| 100 mM | 0.0258 mL | 0.1291 mL | 0.2582 mL | 0.6454 mL |
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