U-14624
Based on 1 Customer Validation
U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.67%
- CAS. Nr.: 14901-16-7
- Formel: C10H9N3S2
- Molecular Weight:235.33
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:150-260 g, Male Sprague-Dawley rats[2]
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Dosage:25 mg/kg
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Administration:I.p.; daily for 3 days
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Result:Prolonged the time required for clearance of pentobarbital from both the plasma and brain, slept significantly longer.
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Animal Model:150-260 g, Male Sprague-Dawley rats[2]
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Dosage:50 mg/kg
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Administration:I.p.; daily for 5-7 days
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Result:Suppressed the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes.
Chemical Information
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CAS. Nr. 14901-16-7
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Appearance Solid
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Molecular Weight 235.33
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Formel C10H9N3S2
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Color Off-white to yellow
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SMILES
S=C(NC1=CC=CC=C1)NC2=NC=CS2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (212.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Von Voigtlander PF, et al. Behavioral and brain catecholamine depleting actions of U-14,624, an inhibitor of dopamine beta-hydroxylase. Proc Soc Exp Biol Med. 1970 Mar;133(3):817-20. [Content Brief]
[2]. Smith JR, et al. Effect of the catecholamine-depleting agent 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624) on drug metabolism in the rat. Biochem Pharmacol. 1980 Sep 15;29(18):2425-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2494 mL | 21.2468 mL | 42.4935 mL | 106.2338 mL |
| 5 mM | 0.8499 mL | 4.2494 mL | 8.4987 mL | 21.2468 mL | |
| 10 mM | 0.4249 mL | 2.1247 mL | 4.2494 mL | 10.6234 mL | |
| 15 mM | 0.2833 mL | 1.4165 mL | 2.8329 mL | 7.0823 mL | |
| 20 mM | 0.2125 mL | 1.0623 mL | 2.1247 mL | 5.3117 mL | |
| 25 mM | 0.1700 mL | 0.8499 mL | 1.6997 mL | 4.2494 mL | |
| 30 mM | 0.1416 mL | 0.7082 mL | 1.4165 mL | 3.5411 mL | |
| 40 mM | 0.1062 mL | 0.5312 mL | 1.0623 mL | 2.6558 mL | |
| 50 mM | 0.0850 mL | 0.4249 mL | 0.8499 mL | 2.1247 mL | |
| 60 mM | 0.0708 mL | 0.3541 mL | 0.7082 mL | 1.7706 mL | |
| 80 mM | 0.0531 mL | 0.2656 mL | 0.5312 mL | 1.3279 mL | |
| 100 mM | 0.0425 mL | 0.2125 mL | 0.4249 mL | 1.0623 mL |
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