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Art. -Nr.: HY-163365

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UTX-143

UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity.

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Formel: C₁₆H₂₁N₇O₂
Molecular Weight:343.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

UTX-143 Chemical Structure

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity^[1].

IC₅₀ & Target

NHE5^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	15.4 μM Compound: 17; UTX-143	Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay	[PMID: 38246115]
NHDF	IC₅₀	>100 μM Compound: 17; UTX-143	Cytotoxicity against HDF cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay Cytotoxicity against HDF cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay	[PMID: 38246115]
TE-1	IC₅₀	4.4 μM Compound: 17; UTX-143	Cytotoxicity against human TE-1 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-1 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-10	IC₅₀	49.5 μM Compound: 17; UTX-143	Cytotoxicity against human TE-10 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-10 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-11	IC₅₀	46.1 μM Compound: 17; UTX-143	Cytotoxicity against human TE-11 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-11 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-15	IC₅₀	5.1 μM Compound: 17; UTX-143	Cytotoxicity against human TE-15 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-15 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-5	IC₅₀	<3.1 μM Compound: 17; UTX-143	Cytotoxicity against human TE-5 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-5 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-6	IC₅₀	22.6 μM Compound: 17; UTX-143	Cytotoxicity against human TE-6 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-6 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-9	IC₅₀	24.6 μM Compound: 17; UTX-143	Cytotoxicity against human TE-9 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-9 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TMK-1	IC₅₀	25.3 μM Compound: 17; UTX-143	Cytotoxicity against human TMK-1 cells expressing HA-tagged full length human NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TMK-1 cells expressing HA-tagged full length human NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]

Chemical Information

Molecular Weight 343.38
Formel C₁₆H₂₁N₇O₂
SMILES

O=C(NC(N)=N)C(N=C1C2=CC=C(C)C=C2)=C(N=C1N(CCO)C)N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shinohara Y, et al. Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound. Bioorg Med Chem. 2024 Feb 1;99:117603. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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UTX-143

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UTX-143 Related Classifications

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