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Art. -Nr.: HY-163778

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ZM600

ZM600 is a potent and orally active antihepatic fibrosis agent. ZM600 decreases the LPS (HY-D1056) induced protein expression of collagen I, α-SM, p-p65. ZM600 has the potential for the research of liver fibrosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₃H₄₁FO₃
Molecular Weight:504.68

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

ZM600 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NF-κB Isoform-spezifische Produkte anzeigen :

In Vitro

ZM600 shows cytotoxicity for LX-2 cells with an IC₅₀ value of 38.17 µM^[1].
ZM600 (0, 5, 10, 20 µM; 2+48 h) decreases the protein and mRNA expression of collagen I and α-SM induced by LPS (HY-D1056) and TGF-β1^[1].
ZM600 (0, 5, 10, 20 µM; 2+2 h) decreases the LPS (HY-D1056) and TGF-β1 induced protein expression of p-p65, p-Smad2/3 and p-AKT in LX-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

LX-2 cells
Concentration:

0, 5, 10, 20 µM
Incubation Time:

2+48 h
Result:

Suppressed LPS (1 µg/mL)-induced protein and mRNA expression of collagen I and α-SMA.

Western Blot Analysis^[1]

Cell Line:

LX-2 cells
Concentration:

0, 5, 10, 20 µM
Incubation Time:

2+2 h
Result:

Decreased the LPS-induced protein expression of p-p65, inhibits TGF-β1-induced phosphorylation of Smad2/3 and AKT in a dose-dependent manner.

In Vivo

ZM600 (15, 30 mg/kg; p.o.; daily for 3 weeks) attenuates CCl4-induced experimental hepatic fibrosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-8 weeks, 18-20 g, Male C57BL/6J mice^[1]
Dosage:

15, 30 mg/kg
Administration:

P.o.; daly from the fifth week until 8 weeks
Result:

Inhibited the infiltration of inflammatory cells and reduced the edema and necrosis of hepatocytes, decreased the deposition of collagens in liver tissues, decreased positive areas of α-SMA in the livers.

Chemical Information

Molecular Weight 504.68
Formel C₃₃H₄₁FO₃
SMILES

[H][C@@]12[C@]([H])([C@@]([H])(CC([C@@]2(CCCC(OC)=O)[H])C(C(C3=CC=C(C(F)=C3)C4=CC=CC=C4)C)=O)CCC5)C5CCC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li G, et al. Discovery of Sophoridine α-Aryl Propionamide Derivative ZM600 as a Novel Antihepatic Fibrosis Agent. J Med Chem. 2024 Jul 11;67(13):11389-11400. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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