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Art. -Nr.: HY-183177

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Zolertine

Zolertine is an α-adrenergic receptor antagonist, with a pK_i of 6.35 for rabbit α₁A-adrenergic receptor and a pK_i of 6.81 for rat α₁B-adrenergic receptor. Zolertine competitively blocks α₁D-adrenergic receptor-mediated vasoconstriction and α₁A-adrenergic receptor-mediated vasoconstriction in arteries. Zolertine can be used in the research of hypertension.

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CAS. Nr.: 4004-94-8
Formel: C₁₃H₁₈N₆
Molecular Weight:258.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Zolertine Chemical Structure

CAS. Nr.: 4004-94-8

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Beschreibung

IC₅₀ & Target^[1]

α1A-adrenergic receptor

6.35 (pKi)

α1B-adrenergic receptor

6.81 (pKi)

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In Vitro

Zolertine (30 min) competes for the α₁-adrenergic receptor binding sites on rat liver (α₁B) and rabbit liver (α₁A) cell membranes, with pK_i values of 6.81 and 6.35, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zolertine appears to exert an antihypertensive effect by reducing blood pressure in Mecamylamine (HY-B1395A)-induced hypertensive dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 4004-94-8
Molecular Weight 258.32
Formel C₁₃H₁₈N₆
SMILES

C1(CCN2CCN(CC2)C3=CC=CC=C3)=NN=NN1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ibarra M, et al. The alpha-adrenoceptor antagonist, zolertine, inhibits alpha1D- and alpha1A-adrenoceptor-mediated vasoconstriction in vitro. J Auton Pharmacol. 2000 Jun;20(3):139-45. [Content Brief]

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Molecular Weight Molecular Weight

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Zolertine

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Zolertine Related Classifications

HY-183177 Related Classifications