4-Hydroxyatomoxetine
Based on 1 Customer Validation
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
For research use only. We do not sell to patients.
- Purity : 96.02%
- CAS No.: 435293-66-6
- Formula: C17H21NO2
- Molecular Weight:271.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1490 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor delta 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor delta 1 expressed in HEK293 cells
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[PMID: 15225731] |
| HEK293 | IC50 |
164 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor mu 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor mu 1 expressed in HEK293 cells
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[PMID: 15225731] |
| HEK293 | IC50 |
88 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor kappa 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor kappa 1 expressed in HEK293 cells
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[PMID: 15225731] |
| HEK293 | IC50 |
>5000 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor like 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor like 1 expressed in HEK293 cells
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[PMID: 15225731] |
Chemical Information
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CAS No. 435293-66-6
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Appearance Solid
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Molecular Weight 271.35
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Formula C17H21NO2
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Color Off-white to yellow
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SMILES
OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC)C(C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (460.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children.
[2]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6853 mL | 18.4264 mL | 36.8528 mL | 92.1319 mL |
| 5 mM | 0.7371 mL | 3.6853 mL | 7.3706 mL | 18.4264 mL | |
| 10 mM | 0.3685 mL | 1.8426 mL | 3.6853 mL | 9.2132 mL | |
| 15 mM | 0.2457 mL | 1.2284 mL | 2.4569 mL | 6.1421 mL | |
| 20 mM | 0.1843 mL | 0.9213 mL | 1.8426 mL | 4.6066 mL | |
| 25 mM | 0.1474 mL | 0.7371 mL | 1.4741 mL | 3.6853 mL | |
| 30 mM | 0.1228 mL | 0.6142 mL | 1.2284 mL | 3.0711 mL | |
| 40 mM | 0.0921 mL | 0.4607 mL | 0.9213 mL | 2.3033 mL | |
| 50 mM | 0.0737 mL | 0.3685 mL | 0.7371 mL | 1.8426 mL | |
| 60 mM | 0.0614 mL | 0.3071 mL | 0.6142 mL | 1.5355 mL | |
| 80 mM | 0.0461 mL | 0.2303 mL | 0.4607 mL | 1.1516 mL | |
| 100 mM | 0.0369 mL | 0.1843 mL | 0.3685 mL | 0.9213 mL |
4-Hydroxyatomoxetine Related Classifications
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