Amquinate
Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection).
For research use only. We do not sell to patients.
- CAS No.: 17230-85-2
- Formula: C18H24N2O3
- Molecular Weight:316.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Biological Activity
Description
In Vitro
Amquinate potently inhibits succinate- and NADH-supported respiration in wild-type Eimeria tenella mitochondria with an IC50 of 1×10-8 M, has no effect on chicken liver mitochondrial respiration at concentrations >1×10-3 M, and does not inhibit succinate dehydrogenase-CoQ reductase or NADH dehydrogenase-CoQ reductase activities at 1×10-4 M[1].
Amquinate shows 100-fold reduced sensitivity in mitochondria from the amquinate-resistant Eimeria tenella mutant, with an IC50 of 1×10-6 M for succinate-supported respiration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Amquinate (2000 ppm; diets) requires a 66.7-fold higher minimal effective dietary dose (2000 ppm) to exhibit anticoccidial activity against amquinate-resistant Eimeria tenella mutant infection in chickens compared to wild-type parasites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eimeria tenella[1]
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Dosage:30 ppm
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Administration:dietary
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Result:Was identified as the minimal effective dose against wild-type Eimeria tenella infection.
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Animal Model:Amquinate-resistant Eimeria tenella mutant[1]
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Dosage:2000 ppm
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Administration:dietary
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Result:Was identified as the minimal effective dose against amquinate-resistant Eimeria tenella mutant infection; Represented a 66.7-fold increase in the minimal effective dose compared to wild-type Eimeria tenella.
Chemical Information
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CAS No. 17230-85-2
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Molecular Weight 316.40
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Formula C18H24N2O3
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SMILES
O=C(OC)C1=CN=C2C=C(C(=CC2=C1O)CCC)N(CC)CC
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Structure Classification
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Initial Source
Mitochondria from Eimeria tenella
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amquinate Related Classifications
HY-114625 Related Classifications
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