CP-94707
CP-94707 is an HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) inhibitor, with an IC50 of 4 μM against wild-type and HIV-1 reverse transcriptase Y181I-Y188L double mutant enzymes, and an IC50 of 10 μM against HIV-1 reverse transcriptase K103N mutant enzyme. CP-94707 inhibits the initiation of negative-strand DNA synthesis primed by tRNALys-3, as well as the elongation of DNA synthesis mediated by HIV-1 reverse transcriptase. CP-94707 can be used in studies related to HIV infection.
For research use only. We do not sell to patients.
- CAS No.: 343250-05-5
- Formula: C21H16N4OS
- Molecular Weight:372.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CP-94,707 (0.10-32 μM; 45 min) inhibits tRNALys-3-primed initiation activity of wild-type HIV-1 RT with an IC50 of 4 μM, retains full activity against Y181I-Y188L double mutant HIV-1 RT (IC50 = 4 μM), and shows only 2.5-fold reduced activity against K103N single mutant HIV-1 RT (IC50 = 10 μM)[1].
CP-94,707 (0.10-32 μM) inhibits elongation activity of wild-type HIV-1 RT with an IC50 of 4 μM, demonstrating no selectivity for initiation over elongation steps[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 343250-05-5
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Molecular Weight 372.44
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Formula C21H16N4OS
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SMILES
O=C1SC2=CC=CC=C2N1CC3=CC=C(N4C(C)=NC5=C4C=CN=C5)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pata JD, et al. Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2004 Jul 20;101(29):10548-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP-94707 Related Classifications
HY-120055 Related Classifications
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