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Cat. No.: HY-161731

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DS08701581

DS08701581 is an inhibitor of FER tyrosine kinase with IC₅₀. DS08701581 has anti-tumor activity and oral activity.

For research use only. We do not sell to patients.

CAS No.: 3074776-78-3
Formula: C₂₆H₃₂N₈O₂
Molecular Weight:488.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DS08701581 Chemical Structure

CAS No.: 3074776-78-3

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

DS08701581 is an inhibitor of FER tyrosine kinase with IC₅₀. DS08701581 has anti-tumor activity and oral activity^[1].

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	0.67 nM Compound: 17c; DS08701581	Inhibition of cell viability in mouse BaF3 cells expressing FER incubated for 3 days by Cell Titer Glo assay Inhibition of cell viability in mouse BaF3 cells expressing FER incubated for 3 days by Cell Titer Glo assay	[PMID: 39015278]
BaF3	GI₅₀	1000 nM Compound: 17c; DS08701581	Inhibition of cell viability in mouse BaF3 cells incubated for 3 days by Cell Titer Glo assay Inhibition of cell viability in mouse BaF3 cells incubated for 3 days by Cell Titer Glo assay	[PMID: 39015278]

Chemical Information

CAS No. 3074776-78-3
Molecular Weight 488.58
Formula C₂₆H₃₂N₈O₂
SMILES

O=C1NN=CC2=C(C#N)C(N[C@H]3[C@@H](N)CCCC3)=NC(NC4=CC=CC(N5C[C@H](C)O[C@H](C)C5)=C4)=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Toru Taniguchi, et al. Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581. ACS Med. Chem. Lett. 2024

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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