BCAS2 - BCAS2 pre-mRNA processing factor Gene

Also Known as DAM1; SPF27; Snt309

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10286

About BCAS2

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,567,557-114,581,615 (from NCBI)

This gene has 2 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in bone marrow (RPKM 27.2), brain (RPKM 25.4) and 25 other tissues.

Summary

Involved in mRNA splicing, via spliceosome. Located in centrosome and nuclear speck. Part of U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. Implicated in breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

BCAS2 Products (1)

mRNA	Protein	Name
NM_005872.3	NP_005863.1	pre-mRNA-splicing factor SPF27

BCAS2 Protein Structure

BCAS2

0
100
200
225 a.a.

Protein Preferred Names	Protein Names
pre-mRNA-splicing factor SPF27	DNA amplified in mammary carcinoma 1 protein

BCAS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BCAS2	O75934	ZWINT	Homo sapiens	O95229	Y2H Array	32296183
Intra	BCAS2	O75934	ZWINT	Homo sapiens	O95229	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	ZWINT	Homo sapiens	O95229	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	BCAS2	O75934	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	BCAS2	O75934	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	BCAS2	O75934	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	SPMIP6	Homo sapiens	Q8NCR6	Validated Y2H	32296183
Intra	BCAS2	O75934	SPMIP6	Homo sapiens	Q8NCR6	Y2H Array	32296183
Intra	BCAS2	O75934	SPMIP6	Homo sapiens	Q8NCR6	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	BCAS2	O75934	KRT37	Homo sapiens	O76014	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	BCAS2	O75934	KRT34	Homo sapiens	O76011	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	PLRG1	Homo sapiens	O43660	Anti Tag CoIP	33961781
Intra	BCAS2	O75934	PLRG1	Homo sapiens	O43660	Anti Tag CoIP	20176811
Intra	BCAS2	O75934	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	BCAS2	O75934	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	BCAS2	O75934	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	BCAS2	O75934	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	BCAS2	O75934	LMO3	Homo sapiens	Q8TAP4-4	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	BCAS2	O75934	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32296183
Intra	BCAS2	O75934	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	BCAS2	O75934	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	BCAS2	O75934	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	KRT36	Homo sapiens	O76013-2	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	BCAS2	O75934	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	BCAS2	O75934	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	LMO2	Homo sapiens	P25791-3	Validated Y2H	32296183
Intra	BCAS2	O75934	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	BCAS2	O75934	CCDC17	Homo sapiens	Q96LX7-5	Validated Y2H	32296183
Intra	BCAS2	O75934	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	KRTAP19-6	Homo sapiens	Q3LI70	Validated Y2H	32296183
Intra	BCAS2	O75934	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	BCAS2	O75934	IFI35	Homo sapiens	P80217-2	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	IFI35	Homo sapiens	P80217-2	Validated Y2H	32296183
Intra	BCAS2	O75934	IFI35	Homo sapiens	P80217-2	Y2H Array	32296183
Intra	BCAS2	O75934	SPMIP5	Homo sapiens	Q8WW14-2	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	SPMIP5	Homo sapiens	Q8WW14-2	Validated Y2H	32296183
Intra	BCAS2	O75934	SPMIP5	Homo sapiens	Q8WW14-2	Y2H Array	32296183
Intra	BCAS2	O75934	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	FAM86C1P	Homo sapiens	Q9NVL1-2	Validated Y2H	32296183
Intra	BCAS2	O75934	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Array	32296183
Intra	BCAS2	O75934	LMO4	Homo sapiens	P61968	Validated Y2H	32296183
Intra	BCAS2	O75934	LMO4	Homo sapiens	P61968	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	LMO4	Homo sapiens	P61968	Y2H Array	32296183
Intra	BCAS2	O75934	MIIP	Homo sapiens	Q5JXC2	Validated Y2H	32296183
Intra	BCAS2	O75934	MIIP	Homo sapiens	Q5JXC2	Y2H Array	32296183
Intra	BCAS2	O75934	MIIP	Homo sapiens	Q5JXC2	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	BCAS2	O75934	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	BCAS2	O75934	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	KRT75	Homo sapiens	O95678	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	BCAS2	O75934	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	PAX5	Homo sapiens	Q02548	Validated Y2H	32296183
Intra	BCAS2	O75934	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	BCAS2	O75934	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	BCAS2	O75934	EMILIN3	Homo sapiens	Q9NT22	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	EMILIN3	Homo sapiens	Q9NT22	Validated Y2H	32296183
Intra	BCAS2	O75934	EMILIN3	Homo sapiens	Q9NT22	Y2H Array	32296183
Intra	BCAS2	O75934	SF3B4	Homo sapiens	Q15427	Anti Tag CoIP	22365833
Intra	BCAS2	O75934	SF3B4	Homo sapiens	Q15427	Y2H	22365833
Intra	BCAS2	O75934	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	BCAS2	O75934	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	BCAS2	O75934	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	BCAS2	O75934	CDC5L	Homo sapiens	Q99459	Anti Tag CoIP	33961781
Intra	BCAS2	O75934	CDC5L	Homo sapiens	Q99459	Y2H	22365833
Intra	BCAS2	O75934	CDC5L	Homo sapiens	Q99459	Crosslink	30021884
Intra	BCAS2	O75934	CDC5L	Homo sapiens	Q99459	Anti Tag CoIP	20176811
Intra	BCAS2	O75934	CDC5L	Homo sapiens	Q99459	Far-WB	20176811
Intra	BCAS2	O75934	CDC5L	Homo sapiens	Q99459	Pull Down	20176811
Intra	BCAS2	O75934	MED29	Homo sapiens	Q9NX70	Validated Y2H	32296183
Intra	BCAS2	O75934	MED29	Homo sapiens	Q9NX70	Y2H Array	32296183
Intra	BCAS2	O75934	MED29	Homo sapiens	Q9NX70	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	PRPF19	Homo sapiens	Q9UMS4	Anti Tag CoIP	20176811
Intra	BCAS2	O75934	PRPF19	Homo sapiens	Q9UMS4	Pull Down	20176811
Intra	BCAS2	O75934	PRPF19	Homo sapiens	Q9UMS4	Y2H	22365833
Intra	BCAS2	O75934	PRPF19	Homo sapiens	Q9UMS4	Anti Tag CoIP	33961781
Intra	BCAS2	O75934	PRPF19	Homo sapiens	Q9UMS4	Far-WB	20176811
Intra	BCAS2	O75934	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	BCAS2	O75934	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	33961781
Intra	BCAS2	O75934	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	22365833
Intra	BCAS2	O75934	PRPF8	Homo sapiens	Q6P2Q9	Y2H	22365833
Intra	BCAS2	O75934	MYOZ3	Homo sapiens	Q8TDC0	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	BCAS2	O75934	MYOZ3	Homo sapiens	Q8TDC0	Y2H Array	32296183
Intra	BCAS2	O75934	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	BCAS2	O75934	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	BCAS2	O75934	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	BCAS2	O75934	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	BCAS2	O75934	GOLGA2	Homo sapiens	Q08379	Validated Y2H	27107012
Intra	BCAS2	O75934	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	GOLGA2	Homo sapiens	Q08379	BFG-2H	27107012
Intra	BCAS2	O75934	PCBD2	Homo sapiens	Q9H0N5	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	PCBD2	Homo sapiens	Q9H0N5	Validated Y2H	32296183
Intra	BCAS2	O75934	PCBD2	Homo sapiens	Q9H0N5	Y2H Array	32296183
Intra	BCAS2	O75934	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	BCAS2	O75934	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	BCAS2	O75934	HGS	Homo sapiens	O14964	Y2H Array	25416956
Intra	BCAS2	O75934	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
Intra	BCAS2	O75934	ACY1	Homo sapiens	Q03154	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	ACY1	Homo sapiens	Q03154	Validated Y2H	32296183
Intra	BCAS2	O75934	ACY1	Homo sapiens	Q03154	Y2H Array	32296183
Intra	BCAS2	O75934	KRT20	Homo sapiens	P35900	Validated Y2H	32296183
Intra	BCAS2	O75934	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	BCAS2	O75934	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	BCAS2	O75934	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	BCAS2	O75934	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	BCAS2	O75934	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	BCAS2	O75934	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	BCAS2	O75934	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	BCAS2	O75934	AIMP2	Homo sapiens	Q13155	Validated Y2H	25416956
Intra	BCAS2	O75934	AIMP2	Homo sapiens	Q13155	Validated Y2H	32296183
Intra	BCAS2	O75934	AIMP2	Homo sapiens	Q13155	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	AIMP2	Homo sapiens	Q13155	Y2H Array	32296183
Intra	BCAS2	O75934	AIMP2	Homo sapiens	Q13155	Y2H Prey Pooling	25416956
Intra	BCAS2	O75934	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	31515488
Intra	BCAS2	O75934	SNRPC	Homo sapiens	P09234	Validated Y2H	32296183
Intra	BCAS2	O75934	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	LMO1	Homo sapiens	P25800	Y2H Array	32296183
Intra	BCAS2	O75934	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
Intra	BCAS2	O75934	ECM1	Homo sapiens	Q16610	Y2H Array	32296183
Intra	BCAS2	O75934	ECM1	Homo sapiens	Q16610	Validated Y2H	32296183
Intra	BCAS2	O75934	ECM1	Homo sapiens	Q16610	Y2H Prey Pooling	32296183
Intra	BCAS2	O75934	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	BCAS2	O75934	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	BCAS2	O75934	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCAS2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7649	BCAS2 Protein, Human (His, T7)	O75934 (A2-F225)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700271	BCAS2 Protein, Human (N-GST)	O75934 (A2-F225)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01400	BCAS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17759	Bcas2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24226	Bcas2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BCAS2	VGNC	VGNC:106650
Canis familiaris	BCAS2	VGNC	VGNC:38399
Felis catus	BCAS2	VGNC	VGNC:69196
Mus musculus	BCAS2	MGD	MGI:1915433
Rattus norvegicus	BCAS2	RGD	RGD:1306485
Macaca mulatta	BCAS2	VGNC	VGNC:106322
Others	BCAS2	NCBI