ADORA2A - adenosine A2a receptor Gene

Also Known as A2aR; RDC8; ADORA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 135

About ADORA2A

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,423,597-24,442,357 (from NCBI)

This gene has 15 transcripts (splice variants), 263 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 12.9), lymph node (RPKM 8.9) and 22 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an Adenosine Receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

ADORA2A Products (7)

mRNA	Protein	Name
NM_001278497.2	NP_001265426.1	adenosine receptor A2a
NR_103543.2
NR_103544.2
NM_001278500.2	NP_001265429.1	adenosine receptor A2a
NM_001278498.2	NP_001265427.1	adenosine receptor A2a
NM_001278499.2	NP_001265428.1	adenosine receptor A2a
NM_000675.6	NP_000666.2	adenosine receptor A2a

ADORA2A Protein Structure

7tm_1

0
100
200
300
412 a.a.

Protein Preferred Names	Protein Names
adenosine receptor A2a	adenosine receptor subtype A2a

ADORA2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADORA2A	P29274	SYNGR1	Homo sapiens	O43759-2	Y2H Prey Pooling	32296183
Intra	ADORA2A	P29274	WLS	Homo sapiens	Q5T9L3-1	Pull Down	28734904
Intra	ADORA2A	P29274	ADORA2A	Homo sapiens	P29274	BiFC	29568380
Intra	ADORA2A	P29274	ADORA2A	Homo sapiens	P29274	BiFC	19013155
Intra	ADORA2A	P29274	NECAB2	Homo sapiens	Q7Z6G3	Y2H	17689978
Intra	ADORA2A	P29274	NECAB2	Homo sapiens	Q7Z6G3	Pull Down	19694902
Intra	ADORA2A	P29274	CNR1	Homo sapiens	P21554	BiFC	28102227
Intra	ADORA2A	P29274	DRD2	Homo sapiens	P14416	BRET	19632986
Intra	ADORA2A	P29274	CNR1	Homo sapiens	P21554	FRET	23296780
Intra	ADORA2A	P29274	ADORA2A	Homo sapiens	P29274	FRET	19013155
Intra	ADORA2A	P29274	ADORA2A	Homo sapiens	P29274	BRET	18675812
Intra	ADORA2A	P29274	NECAB2	Homo sapiens	Q7Z6G3	Pull Down	17689978
Intra	ADORA2A	P29274	DRD2	Homo sapiens	P14416	FRET	19632986
Intra	ADORA2A	P29274	ADORA2A	Homo sapiens	P29274	FRET	29568380
Intra	ADORA2A	P29274	NECAB2	Homo sapiens	Q7Z6G3	Anti Bait CoIP	17689978
Intra	ADORA2A	P29274	ADORA2A	Homo sapiens	P29274	BiFC	18675812
Intra	ADORA2A	P29274	DRD2	Homo sapiens	P14416	BRET	29568380
Intra	ADORA2A	P29274	DRD2	Homo sapiens	P14416	FRET	23296780
Intra	ADORA2A	P29274	ADORA1	Homo sapiens	P30542	BRET	16481441
Intra	ADORA2A	P29274	ADORA1	Homo sapiens	P30542	Anti Tag CoIP	16481441
Intra	ADORA2A	P29274	ADORA2B	Homo sapiens	P29275	BRET	29568380
Intra	ADORA2A	P29274	ADORA2B	Homo sapiens	P29275	FRET	29568380
Intra	ADORA2A	P29274	ADORA2B	Homo sapiens	P29275	BiFC	29568380
Intra	ADORA2A	P29274	ADORA2B	Homo sapiens	P29275	PLA	29568380
Intra	ADORA2A	P29274	CYTH2	Homo sapiens	Q99418	Confocal	16027149
Intra	ADORA2A	P29274	CYTH2	Homo sapiens	Q99418	Anti Tag CoIP	16027149
Intra	ADORA2A	P29274	CYTH2	Homo sapiens	Q99418	Y2H	16027149
Intra	ADORA2A	P29274	CYTH2	Homo sapiens	Q99418	FRET	16027149
Intra	ADORA2A	P29274	CYTH2	Homo sapiens	Q99418	Pull Down	16027149
Intra	ADORA2A	P29274	USP4	Homo sapiens	Q13107	Y2H	16339847
Intra	ADORA2A	P29274	USP4	Homo sapiens	Q13107	Pull Down	16339847
Cross	ADORA2A	P29274	Grm5	Rattus norvegicus	P31424-1	Anti Tag CoIP	12189203
Cross	ADORA2A	P29274	Grm5	Rattus norvegicus	P31424-1	Confocal	12189203

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ADORA2A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700899	ADORA2A Protein-VLP, Human (HEK293)	P29274 (M1-S412)	Purity analysis by SDS-PAGE is not available for VLP proteins.

ADORA2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84242	ADORA2A Antibody (YA3939)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P84242A	ADORA2A Antibody (YA3939)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Basal Ganglia Disease	Basal Ganglia Diseases Basal Ganglia Disorders Abnormality Of The Basal Ganglia
Acute Encephalopathy With Biphasic Seizures And Late Reduced Diffusion	Aesd Aief Acute Infantile Encephalopathy Predominantly Affecting The Frontal Lobes
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Myocardial Stunning
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Dermatitis, Atopic, 7	ATOD7 Dermatitis, Atopic, Susceptibility To, 7 Atopic Dermatitis 7 Dermatitis, Atopic 7
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Sleep Disorder	Sleep Disorders Non-Organic Sleep Disorder
Blepharospasm
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Conduct Disorder
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Subacute Leukemia
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170397	ADORA2A/PDE4D-IN-1		/	Unkown
HY-RS00394	ADORA2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00395	Adora2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00396	Adora2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADORA2A	VGNC	VGNC:59649
Macaca mulatta	ADORA2A	VGNC	VGNC:69704
Bos taurus	ADORA2A	VGNC	VGNC:25687
Rattus norvegicus	ADORA2A	RGD	RGD:2049
Canis familiaris	ADORA2A	VGNC	VGNC:37666
Mus musculus	ADORA2A	MGD	MGI:99402
Others	ADORA2A	NCBI