Hydrolapachol
Hydrolapachol is a mitochondrial respiratory chain inhibitor that targets the site between cytochrome b and c1, and inhibits succinate oxidation in rat liver mitochondria. Hydrolapachol can be used in studies related to mitochondrial respiration.
For research use only. We do not sell to patients.
- CAS No.: 3343-38-2
- Formula: C15H16O3
- Molecular Weight:244.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | IC50 |
20.46 μM
Compound: 7
|
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
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[PMID: 21115213] |
| HL-60 | IC50 |
62.13 μM
Compound: 13
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Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay
Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay
|
[PMID: 17249647] |
| HL-60 | IC50 |
20.46 μM
Compound: 7
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
|
[PMID: 21115213] |
| MDA-MB-435 | IC50 |
20.46 μM
Compound: 7
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Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
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[PMID: 21115213] |
| PBMC | IC50 |
20.46 μM
Compound: 7
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Cytotoxicity against human PBMC cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human PBMC cells after 72 hrs by Alamar Blue assay
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[PMID: 21115213] |
| PBMC | IC50 |
102.34 μM
Compound: 3
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Cytotoxicity against human PBMC after 72 hrs by Alamar blue assay
Cytotoxicity against human PBMC after 72 hrs by Alamar blue assay
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[PMID: 21820768] |
| SF-295 | IC50 |
20.46 μM
Compound: 7
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Cytotoxicity against human SF295 cells after 72 hrs by MTT assay
Cytotoxicity against human SF295 cells after 72 hrs by MTT assay
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[PMID: 21115213] |
In Vitro
Hydrolapachol inhibits succinate oxidation in intact rat liver mitochondria with an IC50 of 1.6 μg per mg protein[1].
Hydrolapachol exerts a stronger inhibitory effect on succinate oxidation in intact rat liver mitochondria at lower pH, and this inhibition is completely reversed by bovine serum albumin, CCCP (HY-100941) and 2,4-dibromophenol, and partially reversed by 2,4-dinitrophenol; at low inhibitor concentrations, phosphate (or arsenate) is required to achieve maximal inhibition of succinate oxidation in intact rat liver mitochondria[1].
Hydrolapachol can be prepared by platinum oxide-platinum black-catalyzed hydrogenation of Isolapachol, and can also be obtained by hydrogenation of lapachol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3343-38-2
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Molecular Weight 244.29
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Formula C15H16O3
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SMILES
O=C1C(O)=C(CCC(C)C)C(C2=C1C=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydrolapachol Related Classifications
HY-183424 Related Classifications
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