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Cat. No.: HY-P11944

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Peptide 22

Peptide 22 is a polypeptide that binds to EGFR. Peptide 22 competes with endogenous EGF for EGFR binding sites and is taken up by triple-negative breast cancer cells in a dose-dependent manner. Peptide 22 can be used in studies related to triple-negative breast cancer.

For research use only. We do not sell to patients.

CAS No.: 3030200-17-7
Formula: C₇₅H₉₆N₁₆O₂₀
Molecular Weight:1541.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Peptide 22 Chemical Structure

CAS No.: 3030200-17-7

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All EGFR Isoforms :

In Vitro

Peptide 22 (YHWYGYTPENVI) (2 μM) specifically binds to EGFR on MDA-MB-468 and MDA-MB-231 triple-negative breast cancer cells, with significantly higher uptake than the parent GE11 peptide and dose-dependent binding saturation at 2 μM in MDA-MB-231 cells^[1].
Peptide 22 shows high uptake in MDA-MB-468 and MDA-MB-231 triple-negative breast cancer cells but has low serum stability, requiring cyclization to enhance in vivo utility^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3030200-17-7
Molecular Weight 1541.66
Formula C₇₅H₉₆N₁₆O₂₀
SMILES

O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H]([C@H](O)C)C(N6[C@@H](CCC6)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC7=CC=C(C=C7)O)N
Sequence

Tyr-His-Trp-Tyr-Gly-Tyr-Thr-Pro-Glu-Asn-Val-Ile
Sequence Shortening

YHWYGYTPENVI
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nag A, et al. Fluorescent Sensors of Phosphate Containing Biomolecules. Israel Journal of Chemistry. 2020 Dec 09;61(3-4):169-184.

[2]. Nisticò N, et al. Development of Cyclic Peptides Targeting the Epidermal Growth Factor Receptor in Mesenchymal Triple-Negative Breast Cancer Subtype. Cells. 2023 Apr 03;12(7):1078. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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