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Sirukumab

(Synonyms: CNTO-136)
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Based on 1 Customer Validation

Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis.

For research use only. We do not sell to patients.

  • Purity: 96.83%
  • CAS No.: 1194585-53-9
  • Molecular Weight:144.58 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sirukumab
  • Experimental Validation Results for Sirukumab
  • Experimental Validation Results for Sirukumab
  • Sirukumab Chemical Structure
    Sirukumab Chemical Structure
CAS No.: 1194585-53-9
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Sirukumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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All Interleukin Related Isoforms

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human IL-6 Protein can bind Sirukumab. The EC50 for this effect is 1.86 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 Siha cells labeling Sirukumab (HY-P99316, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Sirukumab Chemical Structure
    1/16
  • Sirukumab
  • Immobilized Human IL-6 Protein can bind Sirukumab. The EC50 for this effect is 1.86 ng/mL.
  • Flow cytometric analysis of 1.5×106 Siha cells labeling Sirukumab (HY-P99316, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).