2,2′-Dihydroxychalcone
2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties.
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- CAS No.: 15131-80-3
- Formule: C15H12O3
- Masse moléculaire:240.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
1.4 μM
Compound: 92
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Inhibition of fMLP/CB-stimulated release of lysozyme in rat neutrophils
Inhibition of fMLP/CB-stimulated release of lysozyme in rat neutrophils
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[PMID: 17112640] |
| Neutrophil | IC50 |
1.6 μM
Compound: 92
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Inhibition of fMLP/CB-stimulated release of beta-glucuronidase in rat neutrophils
Inhibition of fMLP/CB-stimulated release of beta-glucuronidase in rat neutrophils
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[PMID: 17112640] |
| Neutrophil | IC50 |
5.8 μM
Compound: 23
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| Neutrophil | IC50 |
5.8 μM
Compound: 23
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| PC-3 | IC50 |
10.26 μM
Compound: Page no, R6C2
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Antiproliferative activity against human PC3 cells after 72 hrs by CyQuant dye-based assay
Antiproliferative activity against human PC3 cells after 72 hrs by CyQuant dye-based assay
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[PMID: 30482548] |
2,2′-Dihydroxychalcone (1-50 μM; 72 h) causes a dose-dependent reduction in viability, a concomitant increase in apoptosis in PC3 cells at 72 h, and a decrease in clonogenic survival at 24 h treatment[1].
2,2′-Dihydroxychalcone (15 μM; 6-48 h) markedly decreases the protein levels of Cyclin A and Cyclin B1, cdc2 and PIK1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 cells
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Concentration:1 μM, 5 μM, 15 μM, 25 μM, 50 μM
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Incubation Time:72 h
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Result:Decreaseed PC3 cell viability and inhibited clonogenic survival.
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Cell Line:PC3 cells
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Concentration:1 μM, 5 μM, 15 μM, 25 μM, 50 μM
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Incubation Time:72 h
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Result:Induced apoptosis in PC3 cells.
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Cell Line:PC3 cells
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Concentration:15 μM
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Incubation Time:6 h, 12 h, 24 h, 48 h
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Result:Induced cell cycle arrest in PC3 cells.
Chemical Information
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CAS No. 15131-80-3
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Masse moléculaire 240.25
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Formule C15H12O3
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SMILES
O=C(C1=CC=CC=C1O)C=CC2=CC=CC=C2O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ahmed Q Haddad, et al. Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr Cancer. 2010;62(5):668-81. [Content Brief]
[2]. Kenneth Goh, et al. 2,2'-Dihydroxychalcone, a glutathione transferase inhibitor, sensitises human colon adenocarcinoma cells to chlorambucil and melphalan, but not to actinomycin D. Mol Med Rep. 2008 Jul-Aug;1(4):575-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2,2′-Dihydroxychalcone Related Classifications
HY-W154265 Related Classifications
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