ABBV-4083
ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
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- CAS No.: 1809266-03-2
- Formule: C53H82FNO17
- Masse moléculaire:1024.21
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites[1].
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Dosage:150 mg/kg.
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Administration:PO once daily for 14 days started at 14 weeks post infection (pti).
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Result:Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reduced by >99.9% in the recovered female adult worms.
Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1809266-03-2
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Appearance Solid
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Masse moléculaire 1024.21
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Formule C53H82FNO17
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](C)O[C@](OC[C@H]([C@@H](CC)OC(C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]2C)O[C@]3([H])O[C@H](C)[C@@H](O[C@]4([H])O[C@@H](C)[C@H](OCC5=CC=C(F)C=C5)[C@@](O)(C)C4)[C@H](N(C)C)[C@H]3O)C)O)=O)/C=C(C)/C=C/C2=O)([H])[C@H](OC)[C@@H]1OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (97.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9764 mL | 4.8818 mL | 9.7636 mL | 24.4091 mL |
| 5 mM | 0.1953 mL | 0.9764 mL | 1.9527 mL | 4.8818 mL | |
| 10 mM | 0.0976 mL | 0.4882 mL | 0.9764 mL | 2.4409 mL | |
| 15 mM | 0.0651 mL | 0.3255 mL | 0.6509 mL | 1.6273 mL | |
| 20 mM | 0.0488 mL | 0.2441 mL | 0.4882 mL | 1.2205 mL | |
| 25 mM | 0.0391 mL | 0.1953 mL | 0.3905 mL | 0.9764 mL | |
| 30 mM | 0.0325 mL | 0.1627 mL | 0.3255 mL | 0.8136 mL | |
| 40 mM | 0.0244 mL | 0.1220 mL | 0.2441 mL | 0.6102 mL | |
| 50 mM | 0.0195 mL | 0.0976 mL | 0.1953 mL | 0.4882 mL | |
| 60 mM | 0.0163 mL | 0.0814 mL | 0.1627 mL | 0.4068 mL | |
| 80 mM | 0.0122 mL | 0.0610 mL | 0.1220 mL | 0.3051 mL |
ABBV-4083 Related Classifications
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