Altretamine
Based on 4 publication(s) in Google Scholar
Altretamine is an alkylating antineoplastic agent.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.94%
- CAS No.: 645-05-6
- Formule: C9H18N6
- Masse moléculaire:210.28
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Altretamine
More
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | GI50 |
>10 mM
Compound: 3j
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Photocytotoxicity against human HL60 cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human HL60 cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
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[PMID: 17449247] |
| HL-60 | GI50 |
7.2 mM
Compound: 3j
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Photocytotoxicity against human HL60 cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human HL60 cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
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[PMID: 17449247] |
| LoVo | GI50 |
10.3 mM
Compound: 3j
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Photocytotoxicity against human LoVo cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
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[PMID: 17449247] |
| LoVo | GI50 |
17.2 mM
Compound: 3j
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Photocytotoxicity against human LoVo cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
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[PMID: 17449247] |
| NCTC-2544 | GI50 |
>20 mM
Compound: 3j
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Photocytotoxicity against human NCTC-2544 cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human NCTC-2544 cells irradiated with 1.25 J cm^-2 UVA dose after 72 hrs by MTT assay
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[PMID: 17449247] |
| NCTC-2544 | GI50 |
7.5 mM
Compound: 3j
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Photocytotoxicity against human NCTC-2544 cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
Photocytotoxicity against human NCTC-2544 cells irradiated with 2.5 J cm^-2 UVA dose after 72 hrs by MTT assay
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[PMID: 17449247] |
Altretamine is an antineoplastic agent[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 645-05-6
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Appearance Solid
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Masse moléculaire 210.28
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Formule C9H18N6
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Color White to off-white
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SMILES
CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1
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Synonyms
ENT-50852; RB-1515; WR-95704
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. [Abstract]2025 Apr 15;6(4):102053. PMID: 40187357 -
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
Solvant et solubilité
DMSO : 8.33 mg/mL (39.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.83 mg/mL (3.95 mM); Clear solution
This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocole
Mice[1]
Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7556 mL | 23.7778 mL | 47.5556 mL | 118.8891 mL |
| 5 mM | 0.9511 mL | 4.7556 mL | 9.5111 mL | 23.7778 mL | |
| 10 mM | 0.4756 mL | 2.3778 mL | 4.7556 mL | 11.8889 mL | |
| 15 mM | 0.3170 mL | 1.5852 mL | 3.1704 mL | 7.9259 mL | |
| 20 mM | 0.2378 mL | 1.1889 mL | 2.3778 mL | 5.9445 mL | |
| 25 mM | 0.1902 mL | 0.9511 mL | 1.9022 mL | 4.7556 mL | |
| 30 mM | 0.1585 mL | 0.7926 mL | 1.5852 mL | 3.9630 mL |
Altretamine Related Classifications
HY-B0181 Related Classifications
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