BCA
Based on 8 publication(s) in Google Scholar
BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD).
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- Pureté: 99.99%
- CAS No.: 979-88-4
- Formule: C20H10N2Na2O4
- Masse moléculaire:388.28
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Stockage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BCA
More- Adv Funct Mater. 2024 Mar 14.
- Cardiovasc Diabetol. 2019 Feb 2;18(1):15. [Abstract]
- Mater Today Bio. 2025 Feb 20:31:101598. [Abstract]
- Nano Today. 2025 Jun.
- Nano Today. 2025 Jun.
- Biologics. 2024 May 23:18:129-142. [Abstract]
- J Cancer. 2021 Feb 22;12(8):2243-2257. [Abstract]
- J Oncol. 2022 Aug 11;2022:5824617. [Abstract]
Activité biologique
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BACE1 28 μM (IC50) |
BACE1 43 μM (Ki) |
BCA (20, 40 mg/kg; p.o.; daily for 90 days) reduces the reduction of mitochondrial biogenesis, imbalances of mitochondrial dynamics, and abnormal mitophagy caused by ovariectomy[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old female athymic nude mice[1]
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Dosage:5, 15 mg/kg
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Administration:I.p.; daily
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Result:Reduced the incidence and the growth of estrogen-dependent MCF-7 tumors in a breast cancer xenograft mouse model.
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Animal Model:APP/PS1 mice underwent bilateral ovariectomy[2]
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Dosage:20, 40 mg/kg
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Administration:P.o.; daily for 90 days
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Result:Rescued the reduction of mitochondrial biogenesis, imbalanced of mitochondrial dynamics, and abnormal mitophagy caused by ovariectomy.
Chemical Information
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CAS No. 979-88-4
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Appearance Solid
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Masse moléculaire 388.28
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Formule C20H10N2Na2O4
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Color White to light yellow
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SMILES
O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4
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Synonyms
Disodium bicinchoninate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (8)
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Journal Impact Factor
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Most Recent
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Cardiovasc Diabetol
SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart. [Abstract]2019 Feb 2;18(1):15. PMID: 30710997 -
Mater Today Bio
A metal-polyphenol network-based iron supplement with improved stability and reduced gastrointestinal toxicity for iron deficiency anemia therapy. [Abstract]2025 Feb 20:31:101598. PMID: 40070867 -
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Biologics
LncRNA GAS5 Modulates the Progression of Glioma Through Repressing miR-135b-5p and Upregulating APC. [Abstract]2024 May 23:18:129-142. PMID: 38817552 -
J Cancer
MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma. [Abstract]2021 Feb 22;12(8):2243-2257. PMID: 33758602 -
J Oncol
Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway. [Abstract]2022 Aug 11;2022:5824617. PMID: 36226249
Solvant et solubilité
H2O : 100 mg/mL (257.55 mM; Need ultrasonic)
7.5% Sodium bicarbonate : ≥ 50 mg/mL (128.77 mM)
DMSO : 2 mg/mL (5.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (64.39 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25(9):2158-63. [Content Brief]
[2]. Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056. [Content Brief]
[3]. Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8(10):637. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 7.5% Sodium bicarbonate / H2O | 1 mM | 2.5755 mL | 12.8773 mL | 25.7546 mL | 64.3865 mL |
| 5 mM | 0.5151 mL | 2.5755 mL | 5.1509 mL | 12.8773 mL | |
| 7.5% Sodium bicarbonate / H2O | 10 mM | 0.2575 mL | 1.2877 mL | 2.5755 mL | 6.4387 mL |
| 15 mM | 0.1717 mL | 0.8585 mL | 1.7170 mL | 4.2924 mL | |
| 20 mM | 0.1288 mL | 0.6439 mL | 1.2877 mL | 3.2193 mL | |
| 25 mM | 0.1030 mL | 0.5151 mL | 1.0302 mL | 2.5755 mL | |
| 30 mM | 0.0858 mL | 0.4292 mL | 0.8585 mL | 2.1462 mL | |
| 40 mM | 0.0644 mL | 0.3219 mL | 0.6439 mL | 1.6097 mL | |
| 50 mM | 0.0515 mL | 0.2575 mL | 0.5151 mL | 1.2877 mL | |
| 60 mM | 0.0429 mL | 0.2146 mL | 0.4292 mL | 1.0731 mL | |
| 80 mM | 0.0322 mL | 0.1610 mL | 0.3219 mL | 0.8048 mL | |
| 100 mM | 0.0258 mL | 0.1288 mL | 0.2575 mL | 0.6439 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BCA Related Classifications
HY-15908 Related Classifications
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