Entasobulin
Based on 2 publication(s) in Google Scholar
Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.53%
- CAS No.: 501921-61-5
- Formule: C26H18ClN3O2
- Masse moléculaire:439.89
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Entasobulin
More
Activité biologique
Description
IC50 & Target
β-tubulin polymerization
In Vitro
Entasobulin is a indolizine-glyoxylamide based small molecule that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 501921-61-5
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Appearance Solid
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Masse moléculaire 439.89
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Formule C26H18ClN3O2
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Color White to off-white
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SMILES
O=C(C(NC1=CC(C=CC=N2)=C2C=C1)=O)C3=CN(C4=CC=CC=C43)CC5=CC=C(Cl)C=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
Solvant et solubilité
In Vitro:
DMSO : 155 mg/mL (352.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (246 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Instruction de manipulation (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2733 mL | 11.3665 mL | 22.7330 mL | 56.8324 mL |
| 5 mM | 0.4547 mL | 2.2733 mL | 4.5466 mL | 11.3665 mL | |
| 10 mM | 0.2273 mL | 1.1366 mL | 2.2733 mL | 5.6832 mL | |
| 15 mM | 0.1516 mL | 0.7578 mL | 1.5155 mL | 3.7888 mL | |
| 20 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8416 mL | |
| 25 mM | 0.0909 mL | 0.4547 mL | 0.9093 mL | 2.2733 mL | |
| 30 mM | 0.0758 mL | 0.3789 mL | 0.7578 mL | 1.8944 mL | |
| 40 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4208 mL | |
| 50 mM | 0.0455 mL | 0.2273 mL | 0.4547 mL | 1.1366 mL | |
| 60 mM | 0.0379 mL | 0.1894 mL | 0.3789 mL | 0.9472 mL | |
| 80 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7104 mL | |
| 100 mM | 0.0227 mL | 0.1137 mL | 0.2273 mL | 0.5683 mL |
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