Progabide
Based on 1 Customer Validation
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.50%
- CAS No.: 62666-20-0
- Formule: C17H16ClFN2O2
- Masse moléculaire:334.77
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
GABA receptor[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 62666-20-0
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Appearance Solid
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Masse moléculaire 334.77
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Formule C17H16ClFN2O2
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Color Light yellow to yellow
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SMILES
O=C(N)CCC/N=C(C1=CC=C(Cl)C=C1)\C2=CC(F)=CC=C2O
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Synonyms
SL 76002
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 250 mg/mL (746.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
Male Wistar rats weighing 170 to 240 g are caged in groups of three under diurnal lighting conditions with free access to food and water. The rats are accustomed to handling (housing 1 per cage for 30 min, injecting with saline, 1 mL/100 g body weight) in the period of 7 days before the beginning of the experiment. Progabide is injected as a suspension in saline containing 0.1% Tween 80. Control rats are treated IP with the corresponding vehicle (1 mL/100 g body weight). Ether stress is performed and 15 min after the beginning of the stressful procedure the animals are sacrificed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureté et documentation
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Fiche technique (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9871 mL | 14.9356 mL | 29.8713 mL | 74.6781 mL |
| 5 mM | 0.5974 mL | 2.9871 mL | 5.9743 mL | 14.9356 mL | |
| 10 mM | 0.2987 mL | 1.4936 mL | 2.9871 mL | 7.4678 mL | |
| 15 mM | 0.1991 mL | 0.9957 mL | 1.9914 mL | 4.9785 mL | |
| 20 mM | 0.1494 mL | 0.7468 mL | 1.4936 mL | 3.7339 mL | |
| 25 mM | 0.1195 mL | 0.5974 mL | 1.1949 mL | 2.9871 mL | |
| 30 mM | 0.0996 mL | 0.4979 mL | 0.9957 mL | 2.4893 mL | |
| 40 mM | 0.0747 mL | 0.3734 mL | 0.7468 mL | 1.8670 mL | |
| 50 mM | 0.0597 mL | 0.2987 mL | 0.5974 mL | 1.4936 mL | |
| 60 mM | 0.0498 mL | 0.2489 mL | 0.4979 mL | 1.2446 mL | |
| 80 mM | 0.0373 mL | 0.1867 mL | 0.3734 mL | 0.9335 mL | |
| 100 mM | 0.0299 mL | 0.1494 mL | 0.2987 mL | 0.7468 mL |
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