ABT-418
ABT-418 is a selective neuronal nicotinic acetylcholine receptor ligand with activity in improving spatial memory. ABT-418 administered before training can significantly reduce the spatial discrimination deficit caused by ventricular damage. ABT-418 is considered to be a potential treatment for attention deficit disorder.
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- CAS No.: 147402-53-7
- Formule: C9H14N2O
- Masse moléculaire:166.22
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | EC50 |
64 μM
Compound: 1 (ABT-418)
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Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
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[PMID: 9022806] |
| IMR-32 | EC50 |
64 μM
Compound: ABT-418
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Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in IMR-32 cells using isotopic rubidium efflux assay.
Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in IMR-32 cells using isotopic rubidium efflux assay.
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10.1016/S0960-894X(97)10080-4 |
| PC-12 | EC50 |
214 μM
Compound: 10
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Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)
Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)
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[PMID: 9435889] |
| TE-671 | EC50 |
411 μM
Compound: ABT-418
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Tested for functional activity against alpha-1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflux assay.
Tested for functional activity against alpha-1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflux assay.
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10.1016/S0960-894X(97)10080-4 |
Chemical Information
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CAS No. 147402-53-7
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Masse moléculaire 166.22
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Formule C9H14N2O
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SMILES
CN1[C@H](C2=CC(C)=NO2)CCC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Protocol for Water Maze
The Morris Water Maze is a rodent spatial learning and memory assay in which a mouse or rat swims in opaque water to find an escape platform; in the hidden-platform version, the animal cannot see the platform and must use distal extra-maze cues to learn its fixed spatial location. The assay primarily measures hippocampus-dependent spatial learning during acquisition trials and spatial reference memory during probe trials after platform removal; readouts include escape latency, swim path length, swim speed, quadrant occupancy, platform-site crossings, and proximity to the former platform location.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ABT-418 Related Classifications
HY-14314 Related Classifications
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