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Cat. No.: HY-114625

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Amquinate

Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 17230-85-2
Formule: C₁₈H₂₄N₂O₃
Masse moléculaire:316.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Amquinate Chemical Structure

CAS No.: 17230-85-2

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Activité biologique
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- In Vivo
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Description

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In Vitro

Amquinate potently inhibits succinate- and NADH-supported respiration in wild-type Eimeria tenella mitochondria with an IC₅₀ of 1×10^-8 M, has no effect on chicken liver mitochondrial respiration at concentrations >1×10^-3 M, and does not inhibit succinate dehydrogenase-CoQ reductase or NADH dehydrogenase-CoQ reductase activities at 1×10^-4 M^[1].
Amquinate shows 100-fold reduced sensitivity in mitochondria from the amquinate-resistant Eimeria tenella mutant, with an IC₅₀ of 1×10^-6 M for succinate-supported respiration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Amquinate (30 ppm; diets) exhibits in vivo anticoccidial activity against wild-type Eimeria tenella in chickens, with a minimal effective dietary dose of 30 ppm^[1].
Amquinate (2000 ppm; diets) requires a 66.7-fold higher minimal effective dietary dose (2000 ppm) to exhibit anticoccidial activity against amquinate-resistant Eimeria tenella mutant infection in chickens compared to wild-type parasites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Eimeria tenella^[1]
Dosage:

30 ppm
Administration:

dietary
Result:

Was identified as the minimal effective dose against wild-type Eimeria tenella infection.

Animal Model:

Amquinate-resistant Eimeria tenella mutant^[1]
Dosage:

2000 ppm
Administration:

dietary
Result:

Was identified as the minimal effective dose against amquinate-resistant Eimeria tenella mutant infection; Represented a 66.7-fold increase in the minimal effective dose compared to wild-type Eimeria tenella.

Chemical Information

CAS No. 17230-85-2
Masse moléculaire 316.40
Formule C₁₈H₂₄N₂O₃
SMILES

O=C(OC)C1=CN=C2C=C(C(=CC2=C1O)CCC)N(CC)CC
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Mitochondria from Eimeria tenella
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang CC, et al. Studies of the mitochondria from Eimeria tenella and inhibition of the electron transport by quinolone coccidiostats. Biochim Biophys Acta. 1975;396(2):210-219. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Amquinate

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