Ani9
Based on 2 publication(s) in Google Scholar
Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.12%
- CAS No.: 356102-14-2
- Formule: C17H17ClN2O3
- Masse moléculaire:332.78
-
Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
Membrane Transporter/Ion Channel Compound Library
HY-L011
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Breast Cancer Compound Library
HY-L074
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Mechanoreceptors Compound Library
HY-L095
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Cysteine Targeted Covalent Library
HY-L153
-
Ion Channel Compound Library
HY-L166
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) Ani9
More
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U138-MG | GI50 |
32.44 μM
Compound: 3
|
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
|
[PMID: 32906067] |
| U-251 | GI50 |
18.06 μM
Compound: 3
|
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
|
[PMID: 32906067] |
| U-251 | GI50 |
36.48 μM
Compound: 3
|
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
|
[PMID: 32906067] |
| U-87MG ATCC | GI50 |
32.98 μM
Compound: 3
|
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
|
[PMID: 32906067] |
Ani9 (0-30 μM, 20 min) does not affect the increase of cytoplasmic calcium induced by ATP in FRT cells[1].
Ani9 (1-10 μM, 20 min) inhibits ANO1[1].
Ani9 (0.03-10 μM, 20 min) inhibits CaCC current in PC3, Capan-1, and NHNE cells in a dose-dependent manner, with an IC50 of 110 nM[1].
Ani9 (0-10 μM, 24 h) highly expresses ANO1 in PC3 cells[2].
Ani9 (0.01-10 μM, 48 h) inhibits weakly in prostate cancer, breast cancer, and pancreatic cancer cells[2].
Ani9 (1 μM) inhibits Ca2+-activated Cl- (Clca) in portal vein smooth muscle of Cav1-KO mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 356102-14-2
-
Appearance Solid
-
Masse moléculaire 332.78
-
Formule C17H17ClN2O3
-
Color White to off-white
-
SMILES
O=C(COC1=CC=C(C=C1C)Cl)N/N=C/C2=CC=CC=C2OC
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
2026 Jan 8;17(1):1253. PMID: 41507162 -
Sci Rep
Identification of novel TMEM16A blockers through integrated virtual screening, molecular dynamics, and experimental studies. [Abstract]2025 Apr 29;15(1):15065. PMID: 40301508
Solvant et solubilité
DMSO : ≥ 125 mg/mL (375.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Seo Y, et al. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2. PLoS One. 2016 May 24;11(5):e0155771. [Content Brief]
[2]. Seo Y, et al. Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors. Eur J Med Chem. 2018 Dec 5;160:245-255. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0050 mL | 15.0249 mL | 30.0499 mL | 75.1247 mL |
| 5 mM | 0.6010 mL | 3.0050 mL | 6.0100 mL | 15.0249 mL | |
| 10 mM | 0.3005 mL | 1.5025 mL | 3.0050 mL | 7.5125 mL | |
| 15 mM | 0.2003 mL | 1.0017 mL | 2.0033 mL | 5.0083 mL | |
| 20 mM | 0.1502 mL | 0.7512 mL | 1.5025 mL | 3.7562 mL | |
| 25 mM | 0.1202 mL | 0.6010 mL | 1.2020 mL | 3.0050 mL | |
| 30 mM | 0.1002 mL | 0.5008 mL | 1.0017 mL | 2.5042 mL | |
| 40 mM | 0.0751 mL | 0.3756 mL | 0.7512 mL | 1.8781 mL | |
| 50 mM | 0.0601 mL | 0.3005 mL | 0.6010 mL | 1.5025 mL | |
| 60 mM | 0.0501 mL | 0.2504 mL | 0.5008 mL | 1.2521 mL | |
| 80 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.9391 mL | |
| 100 mM | 0.0300 mL | 0.1502 mL | 0.3005 mL | 0.7512 mL |
Ani9 Related Classifications
HY-119981 Related Classifications
Powered by Bioz