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Cat. No.: HY-P11288A

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ANT308 TFA

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ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 TFA significantly enhances the activation and proliferation of T cells. ANT308 TFA inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 TFA can be used for the study of acute myeloid leukemia (AML) and uveal melanoma (UVM).

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Pureté: 99.57%
Formule: C₁₅₆H₂₆₁N₄₇O₄₀S·xC₂HF₃O₂
Masse moléculaire:3467.10 (free base)

Stockage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ANT308 TFA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform PACAP Receptor :

In Vitro

ANT308 (0.1-10 μM, 72 h) TFA reduces the viability of B16F10 and HT-144 cells dose-dependently^[2].
ANT308 (10 μM, 72 h) TFA decreases the proportion of cells in S phase, and induces apoptosis in B16LS9 and Mel 290 cells^[2].
ANT308 (10 μM, 8 h) TFA significantly inhibits cell migration in the B16LS9, Mel290, and HT-144 cell lines^[2].
ANT308 (72 h) TFA reduces MCAM and N-cadherin expression by inhibiting VIP-VPAC2 signaling^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

B16F10 and HT-144 cells
Concentration:

0.1, 1, 5 and 10 μM
Incubation Time:

72 h
Result:

Decreased the numbers of viable B16F10 and HT-144 cells by around 46% and 27%, respectively, compared to control cultures with 5 μM twice daily.

Cell Cycle Analysis^[2]

Cell Line:

B16LS9 and Mel 290 cells
Concentration:

10 μM
Incubation Time:

72 h
Result:

Decreased cells in the S phase.

Apoptosis Analysis^[2]

Cell Line:

B16LS9 and Mel 290 cells
Concentration:

10 μM
Incubation Time:

72 h
Result:

Increased percentages of apoptotic cells.

Cell Migration Assay ^[2]

Cell Line:

B16LS9, B16F10, Mel 290 cells, HT-144 cells
Concentration:

10 μM
Incubation Time:

8 h
Result:

Significantly inhibited cell migration in the B16LS9, Mel290, and HT-144 cell lines.

In Vivo

ANT308 (100 μg/100 μL PBS, s.c., twice a day for 10 days) TFA reduces the number and size of liver metastases of mice following intraocular or subcutaneous melanoma injection, and shows a trend toward reducing tumor volume at the primary tumor site^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

B16LS9 induced UVM model and B16LS9 or B16LS9 induced subcutaneous melanoma model established in female C57BL6/J mice (8-10 weeks) and NRG (NOD Rag gamma) mice (10-11 months old)^[2]
Dosage:

100 μg/100 μL PBS
Administration:

Subcutaneous injection (s.c.), twice a day for 10 days
Result:

Significantly reduced the number of liver metastases.
Reduced MCAM, but had no significant effect on N-cadherin expression.
had no significant effect on subcutaneous tumor volume.

Chemical Information

Appearance Solid
Masse moléculaire 3467.10 (free base)
Formule C₁₅₆H₂₆₁N₄₇O₄₀S·xC₂HF₃O₂
Color White to off-white
Sequence

Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Ser-Asp-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Leu-Ile-Leu-Asn
Sequence Shortening

KPRRPYTSDYTRLRKQMAVKKYLNLILN
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

DMSO : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (285 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lester C, et al. Chemical Modifications to Enhance the Drug Properties of a VIP Receptor Antagonist (ANT) Peptide. Int J Mol Sci. 2024 Apr 16;25(8):4391.

[2]. Wang W, et al. Targeting the VIP-VPAC Pathway in Melanoma Models Inhibits Tumor Growth and Liver Metastasis. Cancer Lett. 2025 Sep 28;628:217855. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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ANT308 TFA

Peptide Library

Voir tous les produits spécifiques à Isoform PACAP Receptor