Apstatin
Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin shows cardioprotection.
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- CAS No.: 160470-73-5
- Formule: C23H33N5O5
- Masse moléculaire:459.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 2.6 µM (rat APP); 0.64 µM (human APP)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
>20 μM
Compound: 3
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Cytotoxicity against CASP1 knockout human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by celltiter-glo assay
Cytotoxicity against CASP1 knockout human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by celltiter-glo assay
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[PMID: 36724486] |
| MV4-11 | IC50 |
>20 μM
Compound: 3
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Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by celltiter-glo assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by celltiter-glo assay
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[PMID: 36724486] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:270-310 g, Male Wistar rats[1]
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Dosage:1 mg/kg
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Administration:I.v.; 5 min before ischaemia
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Result:Significantly reduced infarct size (IS) in acute myocardial ischaemia.
Chemical Information
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CAS No. 160470-73-5
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Masse moléculaire 459.54
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Formule C23H33N5O5
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SMILES
C[C@@H](C(N)=O)NC([C@H]1N(C([C@H]2N(C([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)CCC2)=O)CCC1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Wolfrum S, et al. Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway. Br J Pharmacol. 2001 Sep;134(2):370-4. [Content Brief]
[2]. Maggiora LL, et al. Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem. 1999 Jul 1;42(13):2394-402. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apstatin Related Classifications
HY-128090 Related Classifications
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