AS1269574 (Standard)
AS1269574 (Standard) is the analytical standard of AS1269574 (HY-107535). This product is intended for research and analytical applications. AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes.
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- CAS No.: 330981-72-1
- Formule: C13H14BrN3O
- Masse moléculaire:308.17
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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HY-107535
AS1269574GPR119 Agonist -
HY-15291
MBX-2982GPR119 Agonist -
HY-15565
APD668GPR119 Agonist -
HY-16673
PSN632408GPR119 Agonist -
HY-12066
GSK1292263 -
HY-15564
AR 231453GPR119 Agonist -
HY-108258
PSN 375963GPR119 Agonist -
HY-15566
APD597GPR119 Agonist -
HY-W011121
2-OleoylglycerolGPR119 Agonist -
HY-15589
GW9508GPR40 Agonist -
HY-15565R
APD668 (Standard)GPR119 Agonist -
HY-12764
6-OAUGPR84 Agonist
Activité biologique
Description
Chemical Information
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CAS No. 330981-72-1
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Masse moléculaire 308.17
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Formule C13H14BrN3O
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SMILES
OCCNC1=NC(C2=CC=C(Br)C=C2)=NC(C)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010;400(3):437-441. [Content Brief]
[2]. Chepurny OG, et al. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30(6):614-629. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS1269574 (Standard) Related Classifications
HY-107535R Related Classifications
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