AY 25674
AY 25674 is an orally active antiallergic agent and a PDE inhibitor. AY 25674 inhibits the release of allergic histamine from mast cells. AY 25674 suppresses passive anaphylaxis induced by reaginic (IgE) antibodies. AY 25674 does not inhibit the increased vascular permeability caused by non-reaginic antibodies, serotonin or histamine. AY 25674 reaches its peak activity shortly after administration; rapid tolerance occurs at high doses. AY 25674 can be used in research related to passive anaphylaxis.
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- CAS No.: 65425-48-1
- Formule: C11H11NO4
- Masse moléculaire:221.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
AY-25,674 exerts a significant inhibitory effect on the enzymatic activity of bovine heart PDE in the in vitro assay for inhibiting bovine heart cyclic 3',5'-PDE activity, with its inhibitory potency being approximately 1/3 that of theophylline[1].
In an in vitro guinea pig lung adenylate cyclase activity assay, AY-25,674 (1×10-4 M; 15 min) only increases the basal activity of PDE-free guinea pig lung adenylate cyclase by 7%, showing no significant direct activating effect on cyclic adenosine monophosphate (cAMP) production[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AY 25674 (10 mg/kg; i.v.) specifically inhibits reagin-mediated increased capillary permeability in rats, with no significant effect on permeability induced by nonreaginic mechanisms or direct mediator action[2].
AY 25674 (0.01-0.3 mg/kg i.p.; 30-300 mg/kg oral; i.p. 15-30 seconds before challenge; oral 5 minutes before challenge) dose-dependently inhibits reagin-mediated histamine release from rat peritoneal mast cells via intraperitoneal and oral routes, with lower potency observed with oral administration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Charles River rats (180-200 g)[2]
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Dosage:0.01-0.3 mg/kg (i.p.); 30-300 mg/kg (oral)
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Administration:i.p. (15-30 seconds before antigen challenge); oral (5 minutes before antigen challenge)
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Result:Inhibited histamine release from sensitized peritoneal mast cells in a dose-dependent manner via both intraperitoneal and oral routes.
Required approximately 100 times more oral dose to achieve comparable inhibition to intraperitoneal administration.
Nonspecific histamine release was 2.2%.
Chemical Information
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CAS No. 65425-48-1
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Masse moléculaire 221.21
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Formule C11H11NO4
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SMILES
O=C(OCC)C(=O)NC1=CC=CC=CC1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AY 25674 Related Classifications
HY-165395 Related Classifications
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