BMS-433771
Based on 1 Customer Validation
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.84%
- CAS No.: 543700-68-1
- Formule: C21H23N5O2
- Masse moléculaire:377.44
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
EC50: 20 nM (RSV)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
13 nM
Compound: 1
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Antiviral activity against Respiratory syncytial virus A2 infected in A549 cells after 3 days by CelltitreGlo assay
Antiviral activity against Respiratory syncytial virus A2 infected in A549 cells after 3 days by CelltitreGlo assay
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[PMID: 23265891] |
| HeLa | CC50 |
>100 μM
Compound: 4; BMS-433771
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 3 days by ATPlite assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 3 days by ATPlite assay
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[PMID: 32407115] |
| HEp-2 | CC50 |
>100 μM
Compound: 5, BMS-433771
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Cytotoxicity against human Hep2 cells assessed as cell viability after 6 days by CCK-8 assay
Cytotoxicity against human Hep2 cells assessed as cell viability after 6 days by CCK-8 assay
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[PMID: 25941547] |
| HEp-2 | EC50 |
0.028 μM
Compound: 5, BMS-433771
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Antiviral activity against Respiratory syncytial virus A infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 6 days by CCK-8 assay
Antiviral activity against Respiratory syncytial virus A infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 6 days by CCK-8 assay
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[PMID: 25941547] |
| HEp-2 | CC50 |
>100 μM
Compound: 3; BMS433771
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Cytotoxicity against human Hep2 cells after 4 days
Cytotoxicity against human Hep2 cells after 4 days
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[PMID: 28772235] |
| HEp-2 | CC50 |
>100 μM
Compound: BMS-433771
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Cytotoxicity against human Hep2 cells after 5 days by CCK8 assay
Cytotoxicity against human Hep2 cells after 5 days by CCK8 assay
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[PMID: 29456794] |
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:rodent models of RSV infection[2]
(cotton rat and mice) -
Dosage:1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
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Administration:oral, single or bid 4 days
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Result:Had prophylactic efficacy via oral dosing in both animal models.
Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.
Chemical Information
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CAS No. 543700-68-1
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Appearance Solid
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Masse moléculaire 377.44
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Formule C21H23N5O2
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Color White to off-white
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SMILES
O=C(N(C1=C2C=CN=C1)CC3=NC4=CC=CC=C4N3CCCCO)N2C5CC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 6.25 mg/mL (16.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2.5 mg/mL (6.62 mM; ultrasonic and adjust pH to 4 with HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother [Content Brief]
[2]. Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.6494 mL | 13.2471 mL | 26.4943 mL | 66.2357 mL |
| 5 mM | 0.5299 mL | 2.6494 mL | 5.2989 mL | 13.2471 mL | |
| DMSO | 10 mM | 0.2649 mL | 1.3247 mL | 2.6494 mL | 6.6236 mL |
| 15 mM | 0.1766 mL | 0.8831 mL | 1.7663 mL | 4.4157 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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