Chol-CTPP
Chol-CTPP is a ligand with dual targeting effect on blood-brain barrier (BBB) and glioma cells. Lip-CTPP can be gained by Chol-CTPP and another mitochondria targeting ligand (Chol-TPP). Lip-CTPP is a promising potential carrier to exert the anti-glioma effect of doxorubicin (DOX) and lonidamine (LND) collaboratively. Lip-CTPP elevates the inhibition rate of tumor cell proliferation, migration and invasion, promote apoptosis and necrosis, and interfere with mitochondrial function.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C144H263N3O53
- Masse moléculaire:2884.62
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Apoptosis, ROS[1]
Lip-CTPP shows satisfying cellular uptake and mitochondrial uptake[1].
Lip-CTPP (0-20 µg/mL DOX and LND, 24 h) shows cytotoxicity and induces apoptosis in C6 cells[1].
Lip-CTPP inhibits intracellular ATP production and has the most severe damage on the membrane potential of mitochondria[1].
Lip-CTPP possesses excellent potential to induce ROS generation[1].
Lip-CTPP (0.5 µg/mL DOX, 48 h) exhibits strong inhibitory effect both on cell migration and invasion[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:C6 cells
-
Concentration:0.1, 0.5, 2.5, 5, 10, and 20 µg/mL of DOX and LND
-
Incubation Time:24 h
-
Result:Showed cytotoxicity on C6 cells in a concentration-dependent manner.
-
Cell Line:C6 cells
-
Concentration:0.5 µg/mL DOX and LND
-
Incubation Time:24 h
-
Result:Performed excellent lethality on C6 cells and the apoptosis and necrosis rate is 3.4 times that of Free DOX + LND.
-
Cell Line:C6 cells
-
Concentration:0.5 µg/mL DOX
-
Incubation Time:48 h
-
Result:Obviously restricted the invasion of C6 cells.
Lip-CTPP can slow down the clearance of free drugs and enhance tumor targeting properties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Kunming mice (male, 20-25 g), 5 µL of C6 cells (2 × 108 cells/mL) were injected into the striatum[1]
-
Dosage:3 mg/kg DOX and LND
-
Administration:Tail vein injection, once on day 4, 7, 10 and 13
-
Result:Increased the survival time, decreased tumor area and the density of tumor cells.
-
Animal Model:Kunming mice (20-25 g)[1]
-
Dosage:10 mg/kg DOX and LND
-
Administration:Tail vein injection (Pharmacokinetics Analysis)
-
Result:Pharmacokinetic parameters of DOX in blood after administration (mean ± SD, n = 3)[1]
parameters AUC(0-t)
(µg/mL*min)MRT (min) Tmax (min) Cmax (µg/mL) t1/2 (min) Clz (L/min/kg) Lip-CTPP 5901.90 ± 406.18 291.30 ± 1.18 30 23.31 ± 0.42 231.06 ± 43.35 1.68 ± 0.13
Pharmacokinetic parameters of DOX in brain after administration (mean ± SD, n = 3)[1]
parameters AUC(0-t)
(µg/mL*min)MRT (min) Tmax (min) Cmax (µg/mL) t1/2 (min) Clz (L/min/kg) Lip-CTPP 1757.61 ± 19.35 
Chemical Information
-
Masse moléculaire 2884.62
-
Formule C144H263N3O53
-
SMILES
O=C(C1=CC=C(C=C1)O)NCCOCCNC(C(CCCC2)=C2C(NCCCCCC(OCCO[C@@H](CC3)CC4=CC[C@]([C@@]5([H])[C@](CC6)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C)([H])[C@@]6([H])[C@]43C)=O)=O)=O.[3].[44]
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Select Batch:Pureté: 99.98%Assay: 99.98%ee.: 99.98%
Références
Calculators
Calculateur de molaritéMass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)= × ×Calculateur de dilutionConcentration (start) × Volume (start) = Concentration (final) × Volume (final)
×=×
Chol-CTPP Related Classifications
Cat. No.: HY-144825
Assay Types -
Powered by Bioz