DA-11004
DA-11004 is an orally active NADP-dependent isocitrate dehydrogenase (IDPc) inhibitor with an IC50 of 1.49 μM. DA-11004 reduces NADPH production, decreases plasma NADPH levels and plasma free fatty acid levels. DA-11004 lowers plasma glucose levels, inhibits fatty acid synthesis in adipose tissue, reduces weight gain and decreases epididymal and retroperitoneal fat content. DA-11004 exerts antidiabetic effects in mice fed a high-fat and high-sugar diet. DA-11004 can be used for research on obesity and type 2 diabetes.
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- CAS No.: 57404-51-0
- Formule: C11H9NO2
- Masse moléculaire:187.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IDPc 1.49 μM (IC50) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, diet-induced obesity model)[1]
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Dosage:30 mg/kg; 100 mg/kg
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Administration:p.o.; daily; 8 weeks
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Result:Reduced final body weight to 30.0 g, epididymal fat weight to 1.26 g, retroperitoneal fat weight to 0.65 g, plasma glucose level to 195.2 mg/dL, plasma triglyceride level to 75.1 mg/dL, plasma total cholesterol level to 99.1 mg/dL, and plasma free fatty acid level to 979 μEq/L at 30 mg/kg.
Reduced final body weight to 24.1 g, epididymal fat weight to 0.63 g, retroperitoneal fat weight to 0.30 g, plasma glucose level to 169.3 mg/dL, plasma triglyceride level to 63.2 mg/dL, plasma total cholesterol level to 105.4 mg/dL, and plasma free fatty acid level to 955 μEq/L at 100 mg/kg.
Dose-dependently inhibited plasma IDPc activity and reduced plasma NADPH levels, with the 100 mg/kg dose producing a greater effect.
Chemical Information
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CAS No. 57404-51-0
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Masse moléculaire 187.20
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Formule C11H9NO2
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SMILES
O=C1C=C(NC)C=2C=CC=CC2C1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DA-11004 Related Classifications
HY-16164 Related Classifications
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