DCDAPH
DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo.
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- CAS No.: 125113-96-4
- Formule: C16H15N3
- Masse moléculaire:249.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
DCDAPH (0-10 μM; 24 h) treatment shows no toxicity to human neuronal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:0, 0.1, 1, and 10 μM
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Incubation Time:24 hours
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Result:Showed no marked toxicity to this human neuronal cell line at 10 μM.
Fluorescent Staining of DCDAPH to Aβ Plaques in Mouse Brain[1].
1. Mouse should be i.v. injected with DCDAPH (0.4 mg/kg, 20% DMSO (HY-Y0320), 80% propylene glycol (HY-Y0921), 50 μL), and sacrificed at 30 min after injection.
2. The brains should be excised, embedded in optimum cutting temperature compound (OCT), and frozen in powdered dry ice immediately.
3. Frozen sections of 20 μm should be cut.
4. Fluorescent observation (Cy5 filter set).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
665
597
Chemical Information
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CAS No. 125113-96-4
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Masse moléculaire 249.31
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Formule C16H15N3
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SMILES
CN(C1=CC=C(/C=C/C=C/C=C(C#N)/C#N)C=C1)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DCDAPH Related Classifications
HY-D1684 Related Classifications
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