Dehydroleucodine
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects.
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- CAS No.: 36150-07-9
- Formule: C15H16O3
- Masse moléculaire:244.29
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa S3 | IC50 |
10 μM
Compound: 1
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Cytotoxicity against human HeLaS3 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay
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[PMID: 27057812] |
| KB | IC50 |
5.3 μM
Compound: 1
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Cytotoxicity against human KB cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human KB cells assessed as decrease in cell viability after 72 hrs by MTT assay
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[PMID: 27057812] |
| MCF7 | IC50 |
5 μM
Compound: 1
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Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 to 96 hrs by MTT assay
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[PMID: 27057812] |
Chemical Information
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CAS No. 36150-07-9
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Appearance Solid
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Masse moléculaire 244.29
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Formule C15H16O3
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Color White to off-white
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SMILES
O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3C(C=C(C)[C@@]31[H])=O)C2=C
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6. [Content Brief]
[2]. Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803. [Content Brief]
[3]. Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dehydroleucodine Related Classifications
HY-122295 Related Classifications
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