Dibenzosuberone
Based on 1 Customer Validation
Dibenzosuberone is a tricyclic compound, commonly referred to as a tricyclic antidepressant (TCA), and is widely used in research on migraine, tension-type headache, anxiety disorder and schizophrenia. Dibenzosuberone also serves as a key intermediate for the synthesis of various active pharmaceutical ingredients (APIs) (e.g., amitriptyline (HY-B0527), nortriptyline (HY-118620), nortriptyline or cyproheptadine (HY-B1622)).
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- Pureté : 99.84%
- CAS No.: 1210-35-1
- Formule: C15H12O
- Masse moléculaire:208.26
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CF1 (female)[2]
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Dosage:50 mg/kg
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Administration:i.p.; daily; 28 days
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Result:Reduced pregnancy rate to 50% relative to controls.
Achieved 65% viable fetuses per litter relative to controls.
Resulted in 0% absolute reabsorptions per litter (0% relative to controls).
Caused 25% death rate in treated females.
Chemical Information
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CAS No. 1210-35-1
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Appearance <32°C Solid,>34°C Liquid
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Masse moléculaire 208.26
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Formule C15H12O
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Color Colorless to light yellow
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SMILES
O=C1C2=CC=CC=C2CCC3=CC=CC=C13
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (480.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (291 KB)
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SDS (453 KB)
- English - EN (453 KB)
- Français - FR (453 KB)
- Deutsch - DE (453 KB)
- Norwegian - NO (453 KB)
- Español - ES (453 KB)
- Swedish - SV (453 KB)
- Italian - IT (453 KB)
- Korean - KR (453 KB)
- Portuguese - PT (453 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Hall IH, et al. Cycloalkanones. 4. Antifertility activity. J Med Chem. 1974 Dec;17(12):1253-7.
[3]. Duarte FS, et al. Evidence for the involvement of the monoaminergic system in the antidepressant-like action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):368-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8017 mL | 24.0085 mL | 48.0169 mL | 120.0423 mL |
| 5 mM | 0.9603 mL | 4.8017 mL | 9.6034 mL | 24.0085 mL | |
| 10 mM | 0.4802 mL | 2.4008 mL | 4.8017 mL | 12.0042 mL | |
| 15 mM | 0.3201 mL | 1.6006 mL | 3.2011 mL | 8.0028 mL | |
| 20 mM | 0.2401 mL | 1.2004 mL | 2.4008 mL | 6.0021 mL | |
| 25 mM | 0.1921 mL | 0.9603 mL | 1.9207 mL | 4.8017 mL | |
| 30 mM | 0.1601 mL | 0.8003 mL | 1.6006 mL | 4.0014 mL | |
| 40 mM | 0.1200 mL | 0.6002 mL | 1.2004 mL | 3.0011 mL | |
| 50 mM | 0.0960 mL | 0.4802 mL | 0.9603 mL | 2.4008 mL | |
| 60 mM | 0.0800 mL | 0.4001 mL | 0.8003 mL | 2.0007 mL | |
| 80 mM | 0.0600 mL | 0.3001 mL | 0.6002 mL | 1.5005 mL | |
| 100 mM | 0.0480 mL | 0.2401 mL | 0.4802 mL | 1.2004 mL |
Dibenzosuberone Related Classifications
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